Exam 1 - Week 1 - Antihistamines

Question 1

MOA of antihistamines

Answer 1

Theorized to block the release of histamine from mast cells and basophils in the nasal passageways that are activated by cold virus inoculation. Antihistamines competitively antagonize histamine at the HI receptor, 1st generation antihistamines also competitively antagonize acetylcholine activity at the muscarinic receptor

Question 2

Examples of 1st gen antihistamines

Answer 2

Benadryl

Question 3

Examples of 2nd gen antihistamines

Answer 3

Claritin and Zyrtec

Question 4

Are 2nd gen antihistamines useful for cough and cold?

Answer 4

No.

Question 5

Anithistamine contraindications

Answer 5

Lactation, neonates, infants