Exam 1 - translocation of GLUT4 to plasma membrane Flashcards
1
Q
What are the steps involved in the translocation of GLUT4 to the plasma membrane
A
- GLUT4 storage vesicles
- tethering
- docking
- fusion
- exocytosis
2
Q
GLUT4 storage vesicles (GSVs)
A
are transported to the cell membrane from GSV pool and endosomes by microtubules and actin
3
Q
tethering
A
an interaction between GSVs and the plasma membrane occur, mediated by a tethering complex
4
Q
Docking
A
GSV docks with the plasma membrane
5
Q
Fusion
A
the lipid bilayer of GSVs and plasma membrane fuse
6
Q
Exocytosis
A
GLUT4 becomes part of the plasma membrane and available for transporting glucose into the cell
7
Q
What does the cell do with all of this glucose coming in?
A
glycolysis
TCA cycle
glycogen
FA Synthesis
