exam 1 review Flashcards
Which class of antibody reacts best at room
temperature?
a)IgG
b)IgM
c)IgE
d)IgA
c)IgM
IgG antibodies are clinically significant for HDN because
A. They are too big to escape the vein
B. They fix compliment
C. They demonstrate dosage
D. They are small enough to cross the placenta
D. They are small enough to cross the placenta
Hemolysis is a positive reaction
that indicates you have most likely identified antibodies that -
a)React at AHG
b)Fix Compliment
c)Cross the placenta
d)Are immune stimulated
b)Fix Compliment
Which of the following is known as the membrane attack complex in the classical pathway?
a)C1
b)C3
c)C4,C2,C3
d)C5bC6C7C8C9
d)C5bC6C7C8C9
True or False: Most Antigens we have discussed are inherited autosomaldominant
a)True
b)False
a)True
A father is Xga+ and his wife is Xga- what will the phenotypes of his offspring be?
a)His daughters will be Xga+ and Sons will be Xga-
b)His daughters will be Xga- and his sons will be Xga+
c)All of his children will be Xga-
d)All of his children will be Xga+
a)His daughters will be Xga+ and Sons will be Xga-
As RBCs are stored which of the following
increases?
a)Plasma potassium
b)2,3 DPG
c)ATP
d)pH
a)Plasma potassium
What is the longest length of time that the
FDA says red cells can be stored for?
a)51 days
b)42 days
c)35 days
d)28 days
b)42 days
When there is a shift to the left, hemoglobin affinity for oxygen does
what?
a)Increases
b)Decreases
a)Increases
What is the maximum time a sample may be obtained before a transfusion for pretransfusion testing?
a)24 hours
b)8 hours
c)3 days
d)7 days
c)3 days
The immunodominant sugar responsible
for group B specificity is
a)N-acetyl galactosamine
b)D-Galactose
c)Fucose
d)N-acetyl glucosamine
b)D-Galactose
What is the most common cause of the
following results?
Anti-A Anti-B A1 cell B cell
3+mf 4+ 0 0
a)Bacterial infection
b)Transfusion
c)Hemolytic disease of the
newborn
d)Immunocompromised
b)Transfusion
Acquired B antigens are found in which
individuals?
A. Bombay individuals
B. Group O persons
C. All blood groups
D. Group A persons
D. Group A persons
Which blood type should NOT result from the union of an AB male to an O female?
A. A
B. B
C. O
D. None of these
C. O
A child is blood typed as A, their mother is blood type B, what blood type must the
father be?
A. A
B. B
C. O
D. Bombay
A. A
Which of the following statement s is true?
A. An individual with AO genotype is
homozygous for A.
B. An individual with BB genotype is
homozygous for B.
C. An individual with OO genotype is
heterozygous for O.
D. An individual with AB genotype is
homozygous for A and B.
B. An individual with BB genotype is
homozygous for B.
What blood type is the following patient?
Anti-A Anti-B A1 cell B cell
0 4+ 4+ 0
A. A
B. B
C. O
D. AB
B. B
Which subgroup do you suspect from the
following results?
Anti-A Anti-B Anti-A,B A1 cell B cell
0 1+mf 1+mf 3+ 0
A. A2
B. A3
C. B3
D. Bel
C. B3
An ABO type on a patient gives the following results, what is your next step?
Anti-A Anti-B A1 cell B cell
4+ 0 0 0
A. Reverse type with A2 cells
B. Forward Type with Anti-A,B
C. Forward Type with A1 lectin
D. Incubate at 4C for 5-10 minutes
D. Incubate at 4C for 5-10 minutes
You would use Ulex europaeus reagent to
investigate what?
A. A subgroup
B. B subgroup
C. Potential Bombay
D. Cold agglutinin
C. Potential Bombay
Which bloodtype has the most amount of H
substance?
A. A1
B. B
C. AB
D. O
D. O
If the patient with the following serological results was a secretor, what substances would that person have in their secretions?
Anti-A Anti-B A1 cell B cell
0 4+ 4+ 0
A. B, Leb
B. Lea
C. Anti-A
D. nothing
A. B, Leb
The Lewis gene codes for a transferase that
transfers a sugar onto precursor substance, what is that sugar?
A. Glucose
B. Fucose
C. Galactose
D. N acetylglucosamine
B. Fucose
A patient has HH, LeLe, sese, A genes.
What antigens will be expressed on
their red cells?
A. A, H, Lea
B. Lea only
C. A only
D. A, H, Lea, Leb
A. A, H, Lea
What test results distinguish an A1 person
from an A2 person?
A. A1 person is A lectin neg and A2
person is A lectin pos
B. A1 person’s plasma antibody is pos
with A2 person’s cells
C. A1 person is A lectin pos and A2
person is A lectin neg
D. A2 person’s plasma antibody is pos
with A1 person’s cells
C. A1 person is A lectin pos and A2
person is A lectin neg
Which antibody reacts with Rhesus - baby cells but not Rhesus- adult cells?
A. Anti-D
B. Anti-C
C. Anti- Du
D. Anti- LW
D. Anti- LW
Which antigens in the Rh system are greater than 20% different between Black
population and Caucasian population?
A. D
B. C
C. e
D. E
B. C
A patient has developed multiple antibodies to the Rh system. Anti-D, Anti-C, and Anti-E. How many units do I have to test to find compatible blood?
A. 33 units
B. 15 units
C. 3 units
D. 1 Rh negative unit
D. 1 Rh negative unit
Which genotype may demonstrate dosage with an anti-C?
A. R0r’
B. RZRZ
C. R2r”
D. rYr’
A. R0r’
Which offspring is not possible from a
mother who is R1R2 and a father who is
R1r?
A. DcE/DcE
B. DCe/DCe
C. DCe/dce
D. DcE/dce
A. DcE/DcE
An individual has the following Rh
phenotype: D+ C- E+ c+ e- Using
Fischer/Race terminology what is
the most likely genotype if they are
Asian?
A. DcE/DcE
B. DCe/DCe
C. DCe/dce
D. DcE/dce
A. DcE/DcE
How are weaker than average reactions with anti-D categorized for donor’s cells?
A. Rh positive
B. Rh negative
C. Rh null
D. Weak D
A. Rh positive
Which population is the Weak D test performed in?
A. Baby
B. Elderly
C. Cardiac
D. Prenatal
A. Baby
What antibodies do you expect to find in
a patient’s plasma who has never been pregnant or transfused and has the following serological results?
Anti-D Anti-C Anti-c Anti-E Anti-e
4+ 4+ 0 4+ 0
A. None
B. Anti-D, Anti-C, Anti-E
C. Anti-c, Anti-e
D. Anti-D only
A. None
Which patient would you expect to make anti-D?
A. Patient who is pregnant
and molecularly tests as D mosaic.
B. Patient who gives weakly reactive
D results in serological testing.
C. Patient who has already made anti-c
D. Patient who is immune compromised and transfused Rh positive blood.
A. Patient who is pregnant
and molecularly tests as D mosaic.
How is testing for Rh antigens and antibodies different from ABO testing?
A. ABO antigens only require room temperature incubation for detection whereas Rh antigens require AHG for detection.
B. Rh antibodies are naturally occurring and are usually present in patient plasma whereas ABO antibodies are not.
C. ABO antibodies can be tested at room temperature whereas D antibodies require AHG for detection.
D. It is not different. They are the same.
C. ABO antibodies can be tested at room temperature whereas D antibodies require AHG for detection.
Which genotype shows the strongest reaction with anti-D
A. DcE/DcE
B. DCe/DCe
C. D–/D–
D. Dce/Dce
C. D–/D–
Rh null cells are which of the following?
A. Shaped like Stomatocytes
B. Serotype as D-C-c+E-e+
C. RhAG positive
D. Highly immunogenic
A. Shaped like Stomatocytes
How would you interpret the following results of an antibody screen?
A. Positive
B. Negative
C. Not valid
IS 37 AHG CC
0 0 0 2+
0 0 0 2+
0 0 0 2+
B. Negative
How would you interpret the following results of phenotype testing?
Anti-A Anti-B Anti-D A1cell Bcell
4+ 0 0 0 4+
A. A positive
B. A negative
C. Antibody Negative
D. Antibody Positive
B. A negative
Which enhancement colloid works by removal of water to concentrate antibody?
A. LISS
B. Polybrene
C. Albumin
D. Polyethylene glycol
D. Polyethylene glycol
Which of the following types of tests does not require the addition of check cells to verify adequate washing?
A. LISS
B. Gel
C. Solid phase
D. PEG
B. Gel
Which is a lab controlled factor in AHG
testing?
A. Temperature
B. Incubation time
C. G-force of centrifuge
D. All of the above
D. All of the above
