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Question 1

Extravascular Autoimmune Hemolysis

Answer 1

Warm Auto

Question 2

Intravascular Autoimmune Hemolysis

Answer 2

Cold Auto (also technically extravascular but the Practice Questions marked Intravascular as correct 🤷‍♂️)

Question 3

Warm Autoimmune Specificity

Answer 3

Frequently Rh

Question 4

Cold Autoimmune Specificity

Answer 4

Frequently I or P

Question 5

DAT: IgG+ & C3d+/-

Answer 5

Warm Autoimmune

Question 6

DAT: IgG- & C3d+

Answer 6

Cold Autoimmune

Question 7

Autoimmune Type that Binds Compliment

Answer 7

Cold Autoimmune

Question 8

Tea Colored Plasma

Answer 8

Drug-Induced Antibody

Question 9

Cefotetan

Answer 9

Drug-Adsorption

Question 10

Streptomycin

Answer 10

Drug-Adsorption

Question 11

Penicillin

Answer 11

Drug-Adsorption

Question 12

Drug-Adsorption Detection Findings

Answer 12

DAT: IgG+, C3d -
Eluate: Negative
Diagnosis: Eluate and ABID Positive with drug coated panel cells only.
Hemolysis: Yes
(Extravascular&raquo_space; Intravascular)

Question 13

Quinidine

Answer 13

Immune Complex

Question 14

Phenacetin

Answer 14

Immune Complex

Question 15

Immune Complex Detection Findings

Answer 15

DAT: IgG+/-, C3d +
Eluate: Negative
Diagnosis: Pt Serum + Drug + ABO Compatible Cells = Hemolysis
Hemolysis: Yes (Intravascular)

Question 16

Cephalosporin

Answer 16

Membrane Modification

Question 17

Membrane Modification Detection Findings

Answer 17

DAT: IgG+, C3d +
Eluate: Negative
Diagnosis: Everything else ruled out
Hemolysis: No

Question 18

Alpha-Methyldopa “Aldomet”

Answer 18

Drug Independent

Question 19

Drug Independent Detection Findings

Answer 19

DAT: IgG+
Eluate: Positive with all cells
Diagnosis: History of the drug
Hemolysis: Yes (Mimics WAIHA)

Question 20

Darzalex

Answer 20

Chemo Drug

Question 21

-umab (Human Monoclonal Antibodies)

Answer 21

Chemo Drug

Question 22

Chemo Drug Detection Findings

Answer 22

DAT: Weak Positive Poly & IgG
Eluate and ABID: Positive with all cells and auto control
Diagnosis: DTT treatment removes the antigen and the ID becomes negative

Question 23

Benign Cold Agglutinins

Answer 23

Anti-i
Anti-I
Anti-IH

Question 24

Pathologic Cold Agglutinins

Answer 24

PCH
CHD

Question 25

CHD Antibody

Answer 25

Anti-I, Wide Thermal Range IgM

Question 26

PCH Antibody

Answer 26

Donnath-Landsteiner IgG specificity to Anti-P