Exam 1 - Orofacial Development Flashcards
During which stage of human development do the germ layers mature and differentiate into specific tissues?
embryonic period
A ____ is formed by the mitotic cleavage of the zygote.
blastomere
A ____ is a group of more than 32 blastomeres.
morula
Which structure of the proliferation period contains a cavity lined with cells?
blastocyst
A ____ is the 64-cell stage morula once it develops an internal blastocystic cavity.
blastocyst
A ____ is the name for a blastocyst once it develops an inner cell mass around day 6-7.
embryoblast
When does implantation of the embryoblast into the uterine wall occur?
day 4-10
The outer cell mass becomes the ____; the inner cell mass becomes the _____.
cytotrophoblast and syncytiotrophoblast layers; bilaminar embryonic disc
Does the cytotrophoblast or syncytiotrophoblast “finger” into the uterine wall?
syncytiotrophoblast
Which layers are precursors to the placenta?
the outer cell mass that becomes the cytotrophoblast and syncytiotrophoblast layers
What are the two layers of the bilaminar embryonic disc?
epiblast
hypoblast
The ____ of the bilaminar embryonic disc forms the ectoderm and then eventually the mesoderm.
epiblast
The ____ of the bilaminar embryonic disc forms the endoderm layer.
hypoblast
What membrane is formed by the enlargement of the amniotic cavity and migration of cells from the hypoblast?
Heuser’s membrane
What structure forms the internal lining of the blastocyst cavity to form the embryonic yolk sac?
Heuser’s membrane
What are the 3 cell layers and 3 embryonic cavities formed and present after complete implantation into the endothelial lining?
epiblast
embryonic mesoderm
hypoblast
amniotic cavity
yolk sac
chorionic cavity
Where is the embryonic mesoderm located?
between the amniotic cavity and yolk sac
Which embryonic cavity surrounds the entire structure/embryo in the uterine wall?
chorionic cavity
During the 3rd week of development, the bilaminar disc is characterized by the formation of the _____.
primitive streak
What structure starts to form from the cells of the epiblast layer migrating and invaginating to form the mesodermal layer?
primitive streak
The primitive node turns into the _____, which turns into the _____.
notochordal process; notochord
The notochord is formed from _____ cells derived from the primitive node.
ectodermal
What blocks further progression of pre-notochordal cells? What is the “road block?”
prechordal plate
Prenotochordal cells invaginate and migrate towards the ____ until they reach the prechordal plate.
cephalad
Prenotochordal cells detach and line up within the _____ layer to form the appropriate midline and form the notochord.
mesoderm
What functions as a primitive axial skeleton for the embryo?
notochord
What establishes the symmetry and polarity of embryonic development?
notochord formation
Does the notochord make somites?
NO
What is the role of the notochord in somite formation?
it INDUCES the formation of somites by other cells
____ are the precursors of the vertebral column, ribs, associated back muscles, and overlying dermis.
Somites
What structure is the precursor to nerves of the spinal column?
neural tube
The notochord stimulates the ____ layer to invaginate and form a round tube called the neural tube.
ectodermal
What cells form the peaks of the groove that eventually fuses together to create the neural tube?
neural crest cells
Where does fusion of the neural tube begin? Where does it fan out to?
starts in the middle; continues outward towards the head and the tail
What embryonic precursor cells eventually make the dorsal root ganglion?
neural crest cells
During the 3rd week of development, the bilaminar disc forms what 3 layers?
ectoderm
mesoderm
endoderm
The ectoderm was formerly the ____ layer.
epiblast
This layer forms the epidermis, hair, skin and nails.
ectoderm
This layer forms the epithelium of the oral and nasal cavities and paranasal sinuses.
ectoderm
This layer forms the salivary and endocrine glands, sweat glands, and the nervous system.
ectoderm
Which embryonic layer forms tooth enamel?
ectoderm
What is paraxial mesoderm?
somites “around the axis”
The ____ mesoderm forms the urogenital system.
intermediate
What are the two subtypes of lateral plate mesoderm?
parietal mesoderm
visceral mesoderm
This layer forms the serous membranes that cover the peritoneal, pleural, and pericardial cavities.
parietal mesoderm
This layer forms the thin serous membranes that cover individual organs.
visceral mesoderm
The endoderm was formerly the ____ layer.
hypoblast
This layer forms the GI tract epithelium and its associated glands.
endoderm
Which developmental defect occurs when the bottom of the neural tube does not fuse, usually from a folic acid deficiency?
spina bifida
Which development defect occurs when extrusion of the dura and arachnoid mater occurs?
meningocele