Exam 1 Chart Information

Question 1

What are the characteristics of a drug with a Vd of 0.05-0.1?

Answer 1

-in plasma
-binds plasma proteins
-polar or non-polar

Question 2

What are the characteristics of a drug with a Vd of 0.1-0.25?

Answer 2

-interstitial/extravascular
-polar is poorly bound to proteins
-lipophilic is highly bound to tissue proteins
-polar or lipophilic

Question 3

What are the characteristics of a drug with a Vd of 0.6-1.0?

Answer 3

-intracellular/total body H2O
-poorly bound to proteins
-lipophilic

Question 4

What are the characteristics of a drug with a Vd of 1.0+?

Answer 4

-in the tissues
-highly bound to tissue proteins
-lipophilic

Question 5

What are the characteristics of glomerular filtration?

Answer 5

-low efficacy
-rate 1/6 of renal perfusion

Question 6

What are the characteristics of tubular secretion?

Answer 6

-high efficacy
-rate equal to renal perfusion

Question 7

What is the relationship between glomerular filtration and tubular secretion?

Answer 7

tubular secretion eliminates what glomerular filtration misses