Exam 1 Flashcards
Hydrophobic bonds
Nonpolar bonds (C-H)
Hydrophilic bonds
Polar (charges on O and N attached to H or C)
Common/important oxidizing agent in cell metabolism
NAD
Most potent oxidizing agent
Oxygen
Amino group more acidic
R-NH3+
Amino group more basic
R-NH2
Carboxylic acid more acidic
R-COOH
Carboxylic acid more basic
R-COO neg
Most common bond between C-H
Covalent
Most frequent type of bond
Polar- covalent
Carbs 3 functions
E source, E storage, cell structure
Lipid (fats) functions
E source, E storage, act as cytokines, form structures like cell membranes
Protein functions
Form structural aspects of cells, act as receptor, transport, “cytokines”, enzyme
Nucleic acid functions
Genetic material, form structure components of cells (ribosomes)
Alpha maltose
Glc-Glc
Sucrose
Glc-Frc
Lactose
Gal-Glc
Main fuel source for most cells
Glucose
Alpha position
Below ring
Beta position
Above ring
Alpha D- glucose
6 ring structure with hydroxyl group on C 1 in alpha position
What’s needed to make arachidonic acid into eicosenoids
COX enzyme
Is alpha or beta D glucose more stable
Beta
D glucose or L glucose physiologically active
D glucose
What formula do all monosaccharides have
C6H12O6
Where do glucose attach in glycogen
Alpha 1,4
Where does branching occur in glycogen
Alpha 1,6
What saccharides make up starch
Amylopectin and amylose
Is amylose branched
No
Is amylopectin more branched than glycogen
No
Name 3 structural carbs/heteropolysaccharides
Alpha-D chondroitin 4 sulfate, hyaluronic acid, heparin
Name 4 monosaccharides
Glucose, sucrose, fructose, ribose
What makes up the extra cellular matrix in connective tissue
Heteropolysaccharides
Are heteropolysaccharides intracellular or extracellular
Extracellular
What are the building blocks of lipids
Fatty acids
Is palmitic acid saturated or unsaturated
Saturated
Is palmitoleic and oleic acid saturated or unsaturated
Unsaturated
Most common type of dietary fat we burn as energy
Triglycerides
Structure of triglycerides
Glycerol connected to 3 fatty acid chains
Structure of phospholipids
Diglyceride connected to 2 fatty acids, a phosphate group, and some alcohol
What type of lipid is amphipathic
Phospholipids
Are fatty acids hydrophilic or hydrophobic
Hydrophobic
Example of a steroid molecule we make
Cholesterol
What can act as a “steroid cytokines”
Cholesterol — can make testosterone, estrogen, progestins, glucocorts
Prostaglandin functions
Mediate inflammation and affects smooth muscle contraction
Thromboxane functions
Promote platelet aggregation and blood clotting
Leukotriene function
Bronchoconstriction and increased capillary permeability — “slow anaphylaxis”
Leukotrienes are produced from arachidonic acid with which enzyme
Lipoxygenase
Name 3 things that influence the conformation of proteins
Temp, pH, ligands
What’s a ligand
Anything that attaches to a protein
What are the building blocks of proteins
Amino acids
What does a peptide bond connect
Carboxylic acid and amino group
Define a primary structure in proteins
Structure of AA sequence in line bond form
Define a secondary structure in proteins
3D structure WITHIN the primary structure (alpha helix, beta pleated sheets, reverse turn)
Define tertiary structure of a protein
3D structure of a whole peptide (fibrous vs. globular)
These are MONOMERIC
Define quaternary structure of a protein
Overall shape of polymeric protein IE: Hgb
What are chains of nucleotides
Nucleic acids
What 3 things is a nucleotide made of
5 C sugar, nitrogenous base, phosphate
What are the purines
AMP, GMP
What are the pyrimidines
DNA- CMP, dTMP
RNA- CMP, UMP
What can form nucleotides with ribose
AMP, GMP, CMP, UMP
What can form nucleotides with deoxyribose
AMP, GMP, dTMP, CMP
What causes antiparallel pairing in DNA
The nitrogenous groups facing each other
How many chromosomes are in a nucleus
46, 23 pairs
Give characteristics of DNA
Long chains, double stranded helix, only in cell nucleus, contains all genetic info, pairing A-T and C-G
Give characteristics of RNA
Short chains; single stranded; found in nucleus, cytoplasm, and ribosomes
How many DNA molecules are in 1 chromosome
1
What makes up a chromosome
DNA and proteins
How many nucleotides do you need for 1 AA
3
What’s a gene
A sequence of nucleotide that codes for AA’s sequence in peptide
Where does protein synthesis occur
In the ribosomes
What is transcription
Where mRNA leaves nucleus through pore to the ribosome
Another name for translation
Protein/polypeptide synthesis
Function of ATP
Energy currency of cell
Function of CoA
Carrier protein for acetyl groups
Function of NAD
Oxidizing agent
Function of neurotransmitters
“Cytokines” — any regulatory molecule
Function of cAMP
Second messenger
Glucose structure