Exam 1

Question 1

Where is GLUT1 located?

Answer 1

most tissue

Question 2

Where is GLUT3 located?

Answer 2

neuronal tissue

Question 3

Where is GLUT2 located?

Answer 3

hepatocytes
pancreatic B cells

Question 4

Where is GLUT4 located?

Answer 4

skeletal myocytes
cardiomyocytes
adipocytes

Question 5

What enzyme is apart of the commitment step for metabolic processes?

Answer 5

hexokinase

Question 6

When insulin is present, does HK expression increase or decrease?

Answer 6

insulin = increased HK

Question 7

What is hexokinase I-III inhibited by but not hexokinase IV?

Answer 7

glucose-6-phosphatase (G6Pase)

Question 8

When PKA is activated, is FBPase-2 or PFK-2 activated?

Answer 8

FBPase-2

Question 9

When FBPase-2 is activated, is glycolysis or gluconeogenesis activated?

Answer 9

gluconeogenesis

Question 10

When PPP-1 is activated, is FBPase-2 or PFK-2 activated?

Answer 10

PFK-2

Question 11

When PFK-2 is activated, is glycolysis or gluconeogenesis activated?

Answer 11

glycolysis

Question 12

When ADP/AMP levels are high, is glycolysis activated or inhibited and why?

Answer 12

activated because by-products of ATP mean its being used and more ATP is needed

Question 13

Is PFK-2 or FBPase-2 activated when glucagon is present?

Answer 13

FBPase-2

Question 14

What is the concentration of glucose when FBPase-2 is activated?

Answer 14

low

Question 15

does PKA or PPP add a phosphate group?

Answer 15

PKA

Question 16

Is glycolysis activated or inhibited when FBPase-2 is active?

Answer 16

inhibited

Question 17

When insulin levels increase, does glycolysis activate or deactivate?

Answer 17

activate

Question 18

when insulin levels increase, does glycogensis activate or deactivate?

Answer 18

activate

Question 19

when insulin levels increase, does PPP-1 increase or decrease?

Answer 19

increase

Question 20

when insulin levels increase, does PFK-2 activate or inactive?

Answer 20

activate

Question 21

when insulin levels increase is AMP/ADP concentrations increase or decrease?

Answer 21

increase

Question 22

What is UDP-glucose?

Answer 22

the active form of glucose

Question 23

what is the branching enzyme in glycogenesis?

Answer 23

glycogen synthase

Question 24

when glucose is debranched, what happens to its solubility?

Answer 24

increases solubility

Question 25

what linkage does the branching enzyme create?

Answer 25

alpha-1,4 linkage

Question 26

PKA activates glycogenisis or glycogenolysis?

Answer 26

glycogenolysis

Question 27

what is the debranching enzyme in glycogenolysis?

Answer 27

alpha-1,6,glucosidse

Question 28

what order does the debranching enzyme remove the linkages?

Answer 28

alpha-1,4-glycosidc then alpha-1,6

Question 29

when talking about glycogen, more phosphorylation means more or less activity?

Answer 29

less activity

Question 30

in glycogenisis, when glycogen synthase is phosphorylated, is it activated or deactivated?

Answer 30

inactivate

Question 31

is glycogen phosphorylase a or b the more active form?

Answer 31

a

Question 32

is glycogen phosphorylase a or b sensitive to internal conditions?

Answer 32

a

Question 33

is glycogen phosphorylase a or b apart of the fight/flight response?

Answer 33

a

Question 34

is phosphorylase kinase activated or inhibited by PKA?

Answer 34

activated

Question 35

is phosphorylase kinase activated or inhibited by Ca2+?

Answer 35

activated

Question 36

in glycogenolysis, is PPP-1 activated or inhibited by insulin?

Answer 36

activated

Question 37

in glycogenolysis, is PPP-1 activated or inhibited by epinephrine and glucagon?

Answer 37

inhibited

Question 38

is PPP-1 or PKA involved in the fight or flight response for glycogen?

Answer 38

PKA