Evaluating misoprostol and machinal methods for induction of labour – RCOG Scientific Impact Paper No. 68 – April 2022 Flashcards
1
Q
What % of births are induced in the UK?
A
30%
2
Q
Misoprostol how long until peak dose
- Oral/sublingual
- Buccally/vaginally
A
- Oral/sublingual: 30 mins
- Buccally/vaginally: 70-80 mins
3
Q
Misoprostol half life
- oral
- vaginal
A
- oral 20-40mins, duration 2 hours
- vaginal 4 hours
- S/L 3 hours
4
Q
How does misoprostol compare to dinoprostone?
A
Misoprostol has lower rates of CS and hyperstimulation
5
Q
Impact of mechanical inductions vs miso?
A
Similar rates of vaginal birth
Balloon 65% less risk of hyper stimulation + fetal heart changes, 52% less risk neonatal morbidity & death
6
Q
Risk of uterine rupture with prostaglandin induction?
A
1.2%
7
Q
What does of misoprostol is given for IOL at term?
A
PO 25mcg 2 hourly
Vaginal 25mcg 4-6 hourly
