Ettinger COPY Flashcards
Which Th mediates immune mediated disease?
Th2
What factors are involve in:
- intrinsic
- extrinsic
- common
- intrinsic: XII, IX, VIII
- extrinsic: tissue factor, VII
- common: X, V , prothrombin (II), fibrinogen(I), XIII
What test will be prolonged first in rodenticide intoxication?
PT (within 36-72 hours)
Scott syndrome:
- results in ____
- affects ____ breed
Defect procoagulant activity on platelet surface
German Shepherd
Hemophilia
- which factor
- results in
- PT/PTT prolongation
A= VIII B = IX
Inhibit formation of tenase complex
PTT elevation
Which cell provide iron necessary for hemoglobin production?
Macrophages
How long does it takes for reticulocytes release?
2-5 days
Which type of IMHA carries the worst prognosis?
Intravascular
Which genetic erythrocyte enzyme deficiency causes impaired erythrocyte energy metabolism?
- Pyruvate kinase (iron overload)
- Phosphofructokinase defiency
- Hereditary spectrum deficiency
- Genetic membrane disorders
What can result in EPO deficiency
- Kidney (peritubular interstitial cells of inner renal vortex and outer medulla)
- PTH
- Hypoalbuminemia
Why does inflammation results in decreased erythropoiesis?
IL-6 increases production of hepcidin which internalize ferroporrietin, prevent release of iron from macrophages and hepatocytes + blocks intestinal iron absorption
Which does hypocobalaminemia results in abnormal erythropoiesis ?
Impaired DNA synthesis within erythroblast
What mutation is associated with polycythemia Vera?
JAK2
Which cancer can result in secondary polycythemia?
Nasal fibrosarcoma, shwannoma , cecal leiomyosarcoma, renal carcinoma/lymphoma/fibrosarcoma
What are the signs of hyperviscosity?
CNS
Hemorrhage
Pu/PD
Vomiting/diarrhea
Antibodies in ITP are directed against what ?
IgG against GPIIb/IIIa
Chediak-Higashi
Breed and describe
Persian
Bleu smoke coat
Results in neutrophils and platelet function defects
Pelger-Huët
Breed and describe
Australian Shepherd
Hyposegmented nuclei
Leucocytes adhésion factors
Breed
Irish setter
Trapped neutrophils syndrome
Breed
Border collies
Progressive myelofibrodis of the bone marrow along with changes in the liver
Pyruvate kinase deficiency
X-linked combined immunodeficiency
Describe
Which cell are affected
Breed
Mutation in the gene encoding for IL-2
CD4 ans CD8 thymocytes
Welsh corgi and basset
Autosomal severe combined deficiency
- describe
- results in
- breed
Mutation in gene of DNA dependent protein kinase
- lymphopenia, hypoglobulinemia
Jack Russel terrier
Which mutation results in cyclic hématopoïèsis of the gray collies
AP3B1
