ETC Inhibitors

Question 1

Complex II (Succinate dehydrogenase)

Answer 1

Malonate
Carboxin
TTFA

Question 2

Complex III (Ubiquinol-ferricytochrome oxidoreductase)

Answer 2

Antimycin

Dimercaprol

Question 3

Complex IV (Cytochrome oxidase)

Answer 3

Cyanide
Carbon monoxide
Sodium azide
Hydrogen sulfide

Question 4

Complex I (NADH Dehydrogenase)

Answer 4

Barbiturate
Piercidin A
Amytal
Rotenone

Question 5

A patient came into the ER for DOB, confusion and headaches. On admission, his breath had a distinct smell of bitter almonds. Your senior recommended treatment with ________ to increase Methemoglobin that will sequester the poison. Which of the following is correct?
A. It inhibits cytochrome oxidase
B. It inhibits NADH dehydrogenase
C. It increases oxidative phosphorylation
D. It increases ATP production

Answer 5

A.

Cyanide inhibits cytochrome oxidase by binding to the ferric state of heme