Autoantibodies

Question 1

Anti-ACh receptor

Answer 1

Myasthenia Gravis

Question 2

Anti-Basement membrane

Answer 2

Goodpasture syndrome

Question 3

Anti-cardiolipin, lupus anticoagulant

Answer 3

SLE, Antiphospholipid syndrome

Question 4

Anticentromere

Answer 4

Limited Scleroderma (CREST syndrome)

Question 5

Anti-desmoglein

Answer 5

Pemphigus vulgaris

Question 6

Anti-dsDNA, Anti-Smith

Answer 6

SLE

Question 7

Anti-glutamate decarboxylase

Answer 7

Type 1 DM

Question 8

Anti-hemidesmosome

Answer 8

Bullous pemphigoid

Question 9

Antihistone

Answer 9

Drug-induced lupus

Question 10

Anti-Jo-1, anti-SRP, anti-Mi-2

Answer 10

Polymyositis, Dermatomyositis

Question 11

Antimicrosomal, antithyroglobulin

Answer 11

Hashimoto thyroiditis

Question 12

Antimitochondrial

Answer 12

Primary biliary cirrhosis

Question 13

Antinuclear antibodies

Answer 13

SLE, nonspecific

Question 14

Anti-Scl70 (anti-DNA topoisomerase I)

Answer 14

Scleroderma (diffuse)

Question 15

Anti-smooth muscle

Answer 15

Autoimmune hepatitis

Question 16

Anti-SSA, anti-SSB (anti-Ro, anti-La)

Answer 16

Sjogren syndrome

Question 17

Anti-TSH receptor

Answer 17

Graves’ disease

Question 18

Anti-U1 RNP (ribonucleoprotein)

Answer 18

Mixed connective tissue disease

Question 19

c-ANCA (PR3-ANCA)

Answer 19

Granulomatosis with polyangitis (Wegener)

Question 20

IgA antiendomysial, IgA anti-tissue transglutaminase

Answer 20

Celiac disease

Question 21

p-ANCA (MPO-ANCA)

Answer 21

Microscopic polyangitis, Churg-Strauss syndrome

Question 22

Rheumatoid factor (antibody, most commonly IgM, specific to IgG Fc region), Anti-CCP

Answer 22

Rheumatoid arthritis