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Endocrine / Misc. > Estrogens / Progestins > Flashcards

Estrogens / Progestins Flashcards

1
Q

Conjugated equine estrogens

A

Natural water soluble estrogen

high dose b/c readily metabolized (0.624 mg)

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2
Q

ethinyl estradiol

A

synthetic steroid estrogen

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3
Q

mestranol

A

synthetic steroid estrogen

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4
Q

diethylstilbestrol (DES)

A

first synthetic nonsteroidal estrogen

not used much today

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5
Q

Pharmacological uses of estrogen

A

Hypogonadism (promote development of female sex organs)

HRT (maintain bone density / suppress hot flashes / suppress urogenital atrophy)

Contraception (negative feedback on HPG axis -> inhibit ovulation)

Acne Tx (suppress steroidogenesis / ↑ SHBG)

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6
Q

Estrogen Side-Effects

A

Breast tenderness (proliferation effect)

Endometrial hyperplasia (use progestin to challenge this)

↑ coagulation (↓ antithrombin)

cholestatis (cholesterol secretion changes)

nausea / migraine / cancer / bloating

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7
Q

Estrogen and Cancer

A

HRT (monotherapy): endometrial CA

Contraception: ↓ ovarian, ↓ endometrial, ↑ breast cancer

due to trophic effecs of hormones + ROS of metabolism

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8
Q

medroxyprogesterone (MPA)

A

Depo-Provera
progestin

Rx: HRT (w/ estrogen) / long acting contraceptive

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9
Q

norethindrone

A

progestin

Rx: contraception

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10
Q

norgestrel

A

progestin

Rx: contraception

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11
Q

Pharmacological Use of Progestins

A

Contraception (negative feedback to HPG axis –> prevent ovulation + ↑ cervical mucus viscosity)

HRT (prevent endometrial hyperplasia)

Dysmenorrhea (decrease SM contractions, prostaglandin production)

Endometriosis (↓ enometrial proliferation)

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12
Q

Progestin Side Effects

A

Break-through bleeding

Impaired glucose tolerance

Lipid metabolism changes

19-nor: acne / hirsutism

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13
Q

Injectable Birth Control

A

“Depo-provera”
(Progesterone)

Estrogen + Progestin

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14
Q

Implant Birth Control

A

Progestin

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15
Q

IUD Birth Control

A

Progestin

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16
Q

Vaginal Ring Birth Control

A

Estrogen + Progestin

17
Q

Transdermal Birth Control

A

Estrogen + Progestin

18
Q

“Emergency” Birth Control – Levien

A

Estrogen + Progestin

19
Q

“Emergency” Birth Control – “Plan-B”

A

Progestin

20
Q

Hormone Contraceptive Side Effects

A

N / HA / Edema / Mastalgia / Breakthrough bleeding (E) / Withddrwal bleed failure / serum protein changes

Breakthrough bleeding (P) / ↑ weight / ↑ skin pigmentation / acne / hirsutism / vaginal infections / amenorrhea

thromboembolic dz / MI / cerebrovascular disease / cholestasis / depression / cancer

21
Q

Oral Birth Control

A

Estrogen + Progestin

Progestin Only

Endocrine / Misc. (8 decks)

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