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Endocrine / Misc. > Antidiabetic Agents > Flashcards

Antidiabetic Agents Flashcards

1
Q

Insulin lispro

A

Rapid-acting Insulin

Duration: 3-5 hours

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2
Q

Insulin aspart

A

Rapid-acting Insulin

Duration: 3-5 hours

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3
Q

Insulin glulisine

A

Rapid-acting Insulin

Duration: 3-5 hours

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4
Q

Inhaled insulin

A

Rapid-acting Insulin

Duration: 3-5 hours

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5
Q

Regular insulin

A

Short-acting insulin

Duration: 4-12 hours

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6
Q

NPH (neutral protamine hagedorn)

A

Intermediate-acting insulin

Duration: 10-20 hours

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7
Q

Glargine

A

Long-acting insulin

duration: 12-20 hours

causes stinging at injection site (acidic)

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8
Q

Detemir

A

Long-acting insulin

duration: 22-24 hours

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9
Q

Metformin

A

MOA: ↓ hepatic glucose output / ↑ peripheral glucose utilization

SE: GI / Vit. B12 deficiency

1st line agent

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10
Q

Glimepiride

A

Sulfonylurea
Rx: diabetes

MOA: inhibition of ATP-sensitive K channel of B cell -> insulin release

SE: ↑ weight, hypoglycemia

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11
Q

Glipizide

A

Sulfonylurea
Rx: diabetes

MOA: inhibition of ATP-sensitive K channel of B cell -> insulin release

SE: ↑ weight, hypoglycemia

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12
Q

Glyburide

A

Sulfonylurea
Rx: diabetes

MOA: inhibition of ATP-sensitive K channel of B cell -> insulin release

SE: ↑ weight, hypoglycemia

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13
Q

Repaglinide

A

Meglitinide
Rx: diabetes

MOA: inhibition of ATP-sensitive K channel of B cell -> insulin release

SE: ↑ weight, hypoglycemia

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14
Q

Nateglinide

A

Meglitinide
Rx: diabetes

MOA: inhibition of ATP-sensitive K channel of B cell -> insulin release

SE: ↑ weight, hypoglycemia

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15
Q

Acarbose

A

Glucosidase Inhibitor
Rx: diabetes

MOA: inhibition of brush border glucosidase enzyme -> ↓ glucose absorption

SE: abdominal pain, Diarrhea, flatulence

contraindicated w/ GI dz

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16
Q

Miglitol

A

Glucosidase Inhibitor
Rx: diabetes

MOA: inhibition of brush border glucosidase enzyme -> ↓ glucose absorption

SE: abdominal pain, Diarrhea, flatulence

contraindicated w/ GI dz

17
Q

Pioglitzone

A

Thiazolidinedione
Rx: diabetes

MOA: activation of PPAR-gamma -> ↑ expression of GLUT4 channel

SE: CV, edema, ↑ weight, hypoglycemia

18
Q

Rosiglitazone

A

Thiazolidinedione
Rx: diabetes

MOA: activation of PPAR-gamma -> ↑ expression of GLUT4 channel

SE: CV, edema, ↑ weight, hypoglycemia

19
Q

pramlintide

A

amylinomimetic
Rx: diabetes

MOA: inhibit glucagon release / inhibit gastric emptying / anoretic effect

SE: N/V, anorexia, hypoglycemia

IV administration only

20
Q

Exenatide

A

Incretin
Rx: diabetes

MOA: potentiate insulin secretion / inhibit glucagon release / inhibit gastric emptying / anoretic effect

SE: N/V/D, hypoglycemia, pancreatitis

21
Q

Sitagliptin

A

dipeptidyl peptidase inhibitor
Rx: diabetes

MOA: inhibit incretin degradation

SE: nasopharyngitis / URI / HA / pancreatitis (acute, hemorrhagic, necrotizing)

oral administration

Endocrine / Misc. (8 decks)

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