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Endocrine / Misc. > Antihistamines > Flashcards

Antihistamines Flashcards

1
Q

Chlorpheniramine

A

1st Generation H1 Antihistamine

Rx: allergic rhinitis

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2
Q

Diphenhydramine

A

1st Generation H1 Antihistamine

Rx: allergic rhinitis, allergic conjunctivitis, urticaria, cough suppressant, relief of motion sickness

Sedative / antiemetic / anticholinergic

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3
Q

Pyrilamine

A

1st Generation H1 Antihistamine

mild sedation, low antimuscarinic, no antimotion sickness activity

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4
Q

Hydroxyzine

A

1st Generation H1 Antihistamine

Rx: antiemetic, sedative, anxiolytic, skin allergies

sedative / anti-emetic

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5
Q

Meclizine

A

1st Generation H1 Antihistamine

Rx: anti-emetic, motion-sickness / vertigo

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6
Q

Promethazine

A

1st Generation H1 Antihistamine

Rx: Anti-emetic / anti-motion sickness

MOA: blocks Na channels in excitable membranes

significant inhibition of Alpha1-adrenergic receptors (postural HTN)

  • anticholinergic*
  • sedative* / anti-emetic

can also block D2 receptors

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7
Q

Cyproheptadine

A

1st Generation H1 Antihistamine

Rx: serotonin syndrome

mild sedation / antimuscarinic actions

↑ appetite / weight gain

anti-serotonin activity

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8
Q

Fexofenadine

A

2nd Generation H1 Antihistamine

Very low sedation

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9
Q

Loratadine

A

2nd Generation H1 Antihistamine

Very low sedation

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10
Q

Desloratadine

A

2nd Generation H1 Antihistamine

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11
Q

Levocetirizine

A

2nd Generation H1 Antihistamine

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12
Q

Cetirizine

A

2nd Generation H1 Antihistamine

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13
Q

Azelastine

A

2nd Generation H1 Antihistamine

MOA: H1 antagonist and inhibits mast cell histamine release

Intranasal or opthalmic

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14
Q

Cromolyn

A

MOA: inhibit mast cell degranulation

Rx: allergic rhinitis / allergic conjunctivitis Tx and prophylaxis

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15
Q

Nedocromil

A

MOA: inhibit mast cell degranulation

Rx: allergic rhinitis / allergic conjunctivitis Tx and prophylaxis

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16
Q

Omalizumab

A

Rx: chronic urticaria / asthma

MOA: recombinant Ab that binds to IgE

Endocrine / Misc. (8 decks)

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