Estrogens an Progestins Flashcards

0
Q

Estrogens side effects?

A
  • endometrial hyperplasia

- hyperplasia of breast ducts and lobules

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1
Q

Estrogens area of use?

A
  • femle hypogondism
  • HRT in menopause(together with progestins)
  • contraception
  • dysmenorrhea
  • acne
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2
Q

Anastrozole moa?

A

works on aromatase(prevent estradiol synthesis)

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3
Q

Clomiphen moa?

A

decreased feedback inhibition of FSH and LH -> stimulates ovulation and pregancy = fertility pill

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4
Q

Tamoxifen areas of use?

A
  • estrogen-dependent breast neoplasia

- prophylaxic treatment of breast cancer

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5
Q

Tamoxifen side effects?

A

possible risk of endometrial cancer

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6
Q

Raloxifene moa and area of use?

A

Estrogen receptor agonist in bone that is used to prevent postmenopausal osteoporosis

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7
Q

Major natural progestin?

A

progesterone

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8
Q

Desogestrel?

A

synthetic progestin without any androgenic and anti-estrogenic activities

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9
Q

Progestin areas og use?

A
  • Contraception
  • ## HRT to oppose estrogen
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10
Q

Progestins side effects?

A
  • lowers HDL and increases LDL
  • glucose intolerance
  • androgenic(hirsutism and acne)
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11
Q

Mifepristone areas of use?

A

abortifacient(morning after pill)

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12
Q

moa of oral contraceptives?

A

estrogens and particularly progestins to suppress the midcycle LH surge, thereby preventing ovulation

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13
Q

estogens side effects?

A
  • breast tenderness - mastalgia
  • nausea
  • headache
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14
Q

oral contraceptives drug interactions?

A

decreased effectiveness in the presence of enzyme inducers

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15
Q

oral contraceptives benefits?

A
  • reduced risk for endometrial and ovarin cancer
  • reduced risk of dysmenorrhea
  • reduced risk for osteoporosis
  • reduced discomfort in endometriosis
  • decreased pelvic inflammatory disease(lowered pH in vagina)