Estrogens an Progestins Flashcards
Estrogens side effects?
- endometrial hyperplasia
- hyperplasia of breast ducts and lobules
Estrogens area of use?
- femle hypogondism
- HRT in menopause(together with progestins)
- contraception
- dysmenorrhea
- acne
Anastrozole moa?
works on aromatase(prevent estradiol synthesis)
Clomiphen moa?
decreased feedback inhibition of FSH and LH -> stimulates ovulation and pregancy = fertility pill
Tamoxifen areas of use?
- estrogen-dependent breast neoplasia
- prophylaxic treatment of breast cancer
Tamoxifen side effects?
possible risk of endometrial cancer
Raloxifene moa and area of use?
Estrogen receptor agonist in bone that is used to prevent postmenopausal osteoporosis
Major natural progestin?
progesterone
Desogestrel?
synthetic progestin without any androgenic and anti-estrogenic activities
Progestin areas og use?
- Contraception
- ## HRT to oppose estrogen
Progestins side effects?
- lowers HDL and increases LDL
- glucose intolerance
- androgenic(hirsutism and acne)
Mifepristone areas of use?
abortifacient(morning after pill)
moa of oral contraceptives?
estrogens and particularly progestins to suppress the midcycle LH surge, thereby preventing ovulation
estogens side effects?
- breast tenderness - mastalgia
- nausea
- headache
oral contraceptives drug interactions?
decreased effectiveness in the presence of enzyme inducers