Antithyroid agents

Question 0

Iodide is converted to iodine by an ………………., an enzyme which can be inhibited by ……………..

Answer 0

Iodide is converted to iodine by an peroxidase, an enzyme which can be inhibited by thioamides

Question 1

what is the basis for the selective cell destruction with radioactive iodide?

Answer 1

Active accumulation/absorption of iodide by the thymocyte

Question 2

The process of organification(iodination of tyrosyl recidues on thyroglobulin) to form ………. and ……….. can be inhibited by …………..

Answer 2

The process of organification(iodination of tyrosyl recidues on thyroglobulin) to form MIT and DIT can be inhibited by Thioamides

Question 3

two types of hypothyroidism that can present with an initial hyperthyroidism?

Answer 3

• Hashimoto

- deQuervain

Question 4

Coupling of MIT and DIT to form T3 and T4 can be inhibited by?

Answer 4

thioamides

Question 5

T4 is converted to T3 by a ……………. in peripheral tissues. This enzyme can be inhibited by the drugs ……………… and ………………….

Answer 5

T4 is converted to T3 by a deiodonase in peripheral tissues. This enzyme can be inhibited by the drugs Propranolol and Propylthiouracil

Question 6

Two drugs to administer during a thyroid storm or a thyrotoxicosis?

Answer 6

propranolol and propylthiouracil

Question 7

two drugs used in uncomplicated hyperthyroid conditions?

Answer 7

Propylthiouracil and Methimazole

Question 8

Thioamides and preganancy?

Answer 8

Propylthiouracil is safer because it is extensively bound to protein. Both thioamides cross the placental barrier.

Question 9

Thyorid hormones and embryonal/fetal development?

Answer 9

It is critiacal for proper neurological development and the development of bones.