Bone and mineral disorders

Question 0

Bisphosphonates moa?

Answer 0

• stabilize hydroxyapatite bone structure

- stimulate osteoblasts to secrete inhibitory chemokines that inhibit osteoclast degradation of bone

Question 1

Bisphosphonates areas of use?

Answer 1

• Pagets disease of bone

- Postmenopausal osteoporosis

Question 2

Pamidronate and etidronate are both?

Answer 2

bisphosphonates

Question 3

what is the principle cell of an osteosarcoma?

Answer 3

the osteoblast.

HMmmmm…. do bisphosphonates increase risk?

Question 4

Teriparatide moa?

Answer 4

Recombinant analogue of PTH: administration once daily stimulates osteoblast and new bone formation. Continous infusion would stimulate osteoclasts and bone degradation

Question 5

Teriparatide side effects?

Answer 5

never use for longer than 2 yrs; increased risk of sarcoma

Question 6

Etanercept moa?

Answer 6

Binds with TNF and prevent inflammation. Used in gout.

Question 7

Probenecid moa in gout? .

Answer 7

Binds with proximal tubule transporters, thereby preventing reuptake of uric acid.