Essential Pharmacology 2

Question 1

What is pharmacology?

Answer 1

The study of the way living systems are affected by chemical agents

Question 2

What is a drug?

Answer 2

Any chemical agent that affects a biological system

Question 3

List some drug sources

Answer 3

1. Natural products from nature
2. Synthetic drugs
3. Biotechnology using living systems to make therapeutic agents
4. Gene therapy to introduce new DNA

Question 4

How do drugs act?

Answer 4

Reacting with a receptor binding site

Question 5

What is drug affinity?

Answer 5

The ability of a drug to interact with its target receptor

Question 6

What is the EC50 value?

Answer 6

The concentration of a drug that gives half the maximal response

Question 7

Low EC50 indicates what affinity?

Answer 7

High affinity

Question 8

Efficacy is determined by what?

Answer 8

How good the drug is at activating the target receptor

Question 9

Size of response of a drug depends on what?

Answer 9

Affinity and efficacy

Question 10

Full agonist drugs act how?

Answer 10

Fully activate and bind to receptors

Question 11

Partial agonists act how?

Answer 11

Bind tightly to receptors but only produce a limited response (low efficacy)

Question 12

Antagonist drugs act how?

Answer 12

Block receptors

Question 13

What types of noradrenaline receptor are there?

Answer 13

Andrenoreceptors; alpha 1 and 2 and beta 1 and 2