Esophagus Flashcards

1
Q

What are the layers of the esophagus?

A
  • mucosa
  • submucosa
  • muscularis propia
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2
Q

What is the blood supply to the esophagus?

A
  • inferior thyroid artery to the cervical esophagus
  • vessels off the aorta to the thoracic esophagus
  • left gastric and inferior phrenic arteries to the abdominal esophagus
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3
Q

What muscle forms the upper esophageal sphincter? What is it innervated by?

A

the cricopharyngeus innervated by the superior laryngeal nerve

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4
Q

What is Killian’s triangle?

A
  • an area in the wall of the pharynx which is a potential weak spot where a Zenker’s can form
  • superior to the cricopharynxgeus muscle and inferior to the inferior constrictor muscles
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5
Q

Where do Zenker’s diverticulum form?

A

in Killian’s triangle, above the cricopharyngeus and below the inferior constrictor muscles

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6
Q

What features on a CXR would support a diagnosis of esophageal perforation?

A
  • pneumomediastinum
  • pleural effusion
  • subcutaneous emphysema
  • pneumothorax
  • sub diaphragmatic air
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7
Q

What is the study of choice to diagnose an esophageal perforation?

A

gastrografin (water soluble) swallow

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8
Q

When should you use gastrografin versus dilute barium?

A
  • gastrografin should generally used first to diagnose a leak because it is less likely to cause problems after extravasation
  • dilute barium can be used because it has higher sensitivity or in patients at high risk of aspiration
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9
Q

What is the most common site of an esophageal perforation? What about the most common site of iatrogenic perf?

A
  • most common: distal esophagus in the left posterolateral aspect 2-3 cm above the GEJ
  • iatrogenic: at the cricopharyngeus
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10
Q

Where is the most common site of iatrogenic esophageal perforation?

A

at the cricopharyngeus

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11
Q

How should a cervical esophageal perforation be managed?

A
  • IVF resuscitation
  • broad spectrum abx (ampicillin, ceftriaxone, flagyl, and fluc)
  • wide local drainage
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12
Q

How should thoracic esophageal perforations be managed in a stable patient?

A
  • IVF resuscitation
  • broad spectrum abx (ampicillin, ceftriaxone, flagyl, fluc)
  • primary repair (left thoracotomy, debride, myotomy to visualize whole mucosal injury, two layer repair with absorbable and permanent suture, buttress, leak test, NGT, mediastinal drain, enteral access, closure)
  • consider esophagectomy depending on etiology
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13
Q

Which patients should have an esophagectomy for perforation?

A

those with malignancy, caustic perforation, or burned out megaesophagus from achalasia

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14
Q

How should thoracic esophageal perforation be managed in an unstable patient?

A

exclusion and diversion
- closure of perforation over a T-tube
- mediastinal drainage
- cervical esophagostomy
- J-tube placement

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15
Q

What defines achalasia?

A

incomplete relaxation of the LES with peristalsis or hypotonic esophageal contractions

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16
Q

What are the three types of achalasia?

A
  • type I: normal esophageal pressure with apersitalsis and impaired LES relaxation
  • type II: increased intraesophageal pressure, absent peristalsis, impaired LES relaxation
  • type III: distal esophageal spastic contractions, absent peristalsis, impaired LES relaxation
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17
Q

Bird’s beak is used to describe what esophageal pathology?

A

achalasia

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18
Q

What is the etiology of achalasia?

A

degenerative loss of NO-producing inhibiting neurons within the LES

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19
Q

What is pseudoachalasia?

A

achalasia caused by malignancy

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20
Q

What is the treatment for achalasia?

A
  • lap Heller myotomy with partial fundoplication (6cm onto esophagus, 2cm onto stomach)
  • endoscopic therapies increase the rate of surgical complications in subse
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21
Q

What is the treatment for achalasia?

A
  • lap Heller myotomy with partial fundoplication (6cm onto esophagus, 2cm onto stomach)
  • endoscopic therapies increase the rate of surgical complications in subsequent interventions and are thus avoided in healthy patients that can undergo surgery
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22
Q

If a patient with achalasia is undergoing balloon dilation and a perforation is caused, what is the next step?

A

repair with myotomy at the same time

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23
Q

What is isolated hypertensive LES?

A

high basal LES with complete relaxation and normal peristalsis

24
Q

How is isolated hypertensive LES treated?

A
  • calcium channel blockers
  • nitrates
  • heller
25
What is the difference between diffuse esophageal spasm and nutcracker esophagus?
diffuse esophageal spasm is characterized by uncoordinated contractions while nutcracker is characterized by coordinated ones
26
How are diffuse esophageal spasm and nutcracker esophagus treated?
- calcium channel blockers - nitrates - long-segment heller
27
How are Zenker's diverticuli managed?
- less than 3cm: open mytoomy via left neck with or without diverticulectomy (resection or suspension) - more than 3cm: endoscopic division of cricopharyngeus
28
What is an epiphrenic esophageal diverticulum and how is it managed?-
- a type of pulsion diverticulum associated with esophageal dysmotility - treated with diverticulectomy and treatment of the dysmotility, usually with heller
29
How is a mid-esophageal diverticulum treated?
VATS diverticulectomy and myotomy if symptomatic
30
What is unique about a mid-esophageal diverticulum?
- a traction (true) diverticulum - usually associated with a lead point/inflammatory condition - treated with diverticulectomy if symtpomatic
31
What is Barrett's esophagus?
a metaplasia of the lower esophagus from squamous to columnar epithelium
32
What is the recommended surveillance for Barrett's esophagus?
- annual EGD with four quadrant biopsies every 1-2 cm - repeat immediately if high-grade dysplasia is found - repeat in 6 months if low-grade dysplasia is found - can go to every three years after two years without dysplasia
33
How is high-grade dysplasia treated in those undergoing Barrett's esophagus?
- first step is to repeat EGD with biopsies to confirm - second step is endoscopic mucosal resection
34
What are the risk factors for adenocarcinoma and SCC of the esophagus?
- adenocarcinoma: male, western country, obesity, GERD, Barrett's - SCC: male, eastern country, alcohol, smoking
35
How is esophageal cancer worked up and staged?
- H&P with standard labs - endoscopy with biopsy - add bronchoscopy if above the carina - CT chest/abdomen - PET - EUS of suspicious nodes
36
How is esophageal cancer staged?
- T1a: invades lamina propria or muscularis mucosa- - T1b: invades the submucosa - T2: invades muscularis mucosa - T3: invades adventitia - T4: invades surrounding structures - N1: involves 1-2 nodes - N2: involves 3-6 nodes - N3: involves >7 nodes
37
How does the location of an esophageal cancer change management?
those less than 5cm from the cricopharyngeus are considered unresectable and thus receive definitive chemoradiation
38
Which esophageal cancers are candidates for endoscopic resection and ablation?
high grade dysplasia, Tis, and T1a tumors less than 2 cm that are well-to-moderately differentiated
39
Which esophageal cancer patients get neoadjuvant chemoradiation?
those with a T2 lesion or any nodal disease
40
What makes esophageal cancer unresectable?
distant mets or invasion of aorta/vertebrae/trachea
41
What structures can esophageal cancers invade while remaining resectable?
- pericardium - pleura - diaphragm
42
Neoadjuvant chemotherapy for esophageal cancer is based on what agents?
fluorouracil or taxanes
43
Which esophageal cancers get upfront esophagectomy?
T1b lesions without nodal disease
44
What is an Ivor-lewis esophagectomy?
- laparotomy and right thoracotomy with upper thoracic esophagogastric anastomosis - good for distal tumors
45
What is a McKeown esophagectomy?
- similar to Ivor lewis (laparotomy and right thoracotomy) but with cervical anastomosis
46
What is a transhiatal esophagectomy?
- laparotomy with left cervical incision and cervical anastomosis - cervical leaks are better tolerated and avoids thoracotomy - but limits lymph node harvest and difficult to mobilize large, mid-thoracic tumors - equal long-term survival
47
Which is better tolerated, a thoracic or cervical esophageal leak?
cervical
48
If a gastric conduit is not available for esophageal reconstruction, what is the next best option?
a colon interposition conduit
49
What does the gastric conduit survive on for blood supply in an esophagectomy?
the right gastroepiploic
50
Who gets adjuvant therapy for esophageal cancer?
everyone except those with SCC and those with T1N0 adenocarcinoma that had an R0 resection
51
What is Fanconi anemia?
a combination of SCC of the head/neck/esophagus and pancytopenia
52
What is the most common benign tumor of the esophagus?
a leiomyoma
53
How are esophageal leiomyomas managed?
- enucleation for those that are symptomatic or larger than 5cm - do not biopsy these as it makes resection more difficult
54
Patient with long-standing GERD now has dysphagia and a narrowed ring of mucosa just above the GEJ on endoscopy.
- has a schatzki ring - treat with dilatation and PPI
55
How is the esophagus approached based on the level?
- cervical: left - mid-thoracic: right - low thoracic: left