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HEMA > ERYTHROPOIESIS - MEGAKARYOPOIESIS > Flashcards

ERYTHROPOIESIS - MEGAKARYOPOIESIS Flashcards

1
Q

nucleated RBC precursors are called

A

Erythroblast

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2
Q

erythrocyte precursors develop from two progenitors

A
  1. burst-forming unit-erythroid (large colonies)
  2. colony-forming unit-erythroid (small colony)
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3
Q

it takes __-__ days for precursors to become mature enough to enter the circulation

A

6-7 days

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4
Q

Pronormoblast, Rubriblast, Proerythroblast. Nucleus:

A

8:1, round tooval, containing 1-2 nucleoli

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5
Q

Pronormoblast, Rubriblast, Proerythroblast. Cytoplasm

A

Dark Blue

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6
Q

Pronormoblast, Rubriblast, Proerythroblast. Location

A

Bone marrow

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7
Q

Cellular activity: begins to accumulate necessary for hemoglobin production

A

Pronormoblast, Rubriblast, Proerythroblast

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8
Q

Pronormoblast, Rubriblast, Proerythroblast. Life span

A

slightly more than 24hrs

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9
Q

Basophilic normoblast, Prorubricyte, Basophilic erythroblast. Size

A

12-17 um

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10
Q

Pronormoblast, Rubriblast, Proerythroblast. size

A

14-20 um

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11
Q

Basophilic normoblast, Prorubricyte, Basophilic erythroblast. cytoplasm

A

deeper blue

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12
Q

Basophilic normoblast, Prorubricyte, Basophilic erythroblast. life span

A

slightly more than 24hrs

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13
Q

Cellular activity: detectable hemoglobin synthesis occur

A

Basophilic normoblast, Prorubricyte, Basophilic erythroblast

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14
Q

Polychromatic normoblast, Rubricyte, Polychromatic erythroblast. size

A

10-15 um

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15
Q

Polychromatic normoblast, Rubricyte, Polychromatic erythroblast. nucleus

A

4:1, no nuclei present

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16
Q

Polychromatic normoblast, Rubricyte, Polychromatic erythroblast. cytoplasm

A

gray-blue

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17
Q

cellular activity: capable of undergoing mitosis, hemoglobin synthesis increases

A

Polychromatic normoblast, Rubricyte, Polychromatic erythroblast.

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18
Q

Polychromatic normoblast, Rubricyte, Polychromatic erythroblast. life span

A

approx. 30 hrs

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19
Q

Orthrochromic normoblast, Metaubricyte, Orthrochromic erythroblast. Nucleus

A

1:2, nucleus is completely condensed

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20
Q

Orthrochromic normoblast, Metaubricyte, Orthrochromic erythroblast. cytoplasm

A

salmon pink

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21
Q

Orthrochromic normoblast, Metaubricyte, Orthrochromic erythroblast. life span

A

approx. 48 hrs

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22
Q

Cellular activity: the nucleus is ejected from the cell

A

Orthrochromic normoblast, Metaubricyte, Orthrochromic erythroblast

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23
Q

Polychromatic erythrocyte, Reticulocyte. nucleus

A

no nuclei present

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24
Q

Polychromatic erythrocyte, Reticulocyte. cytoplasm

A

salmon pink, shape is still not biconcave

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25
Q

Polychromatic erythrocyte, Reticulocyte. location

A

resides in bone marrow for 1-2 days, them moves to the peripheral blood for 1 day before reaching maturity

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26
Q

cellular activity: complete hemoglobin production

A

Polychromatic erythrocyte, Reticulocyte

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27
Q

life span: 2-3 days, reside in bone marrow for 1-2 days then moves to peripheral blood for 1 day

A

Polychromatic erythrocyte, Reticulocyte

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28
Q

granulocyte that react with both basic and acid stain

A

Neutrophil and Basophil

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29
Q

granulocyte that react with acid stain only

A

Eosinophil

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30
Q

Erythrocyte cytoplasm

A

salmon pink, biconcave shape 1/3 central palor

31
Q

glyctoprotein hormone produce in the renal peritubular interstitial cells

A

erythropoietin

32
Q

produced in the kidney, and acting at a distant location

A

erythropoietin

33
Q

3 major effects of erythropoietin

A
  1. allowing early release of reticulocytes from the bone marrow
  2. preventing apoptotic cell death
  3. reducing time needed for cells to mature in the bone marrow
34
Q

programmed cell death

A

apoptosis

35
Q

cell injury caused by inflammation

A

necrosis

36
Q

Leukopoiesis is divided into two major categories

A
  1. Myelopoiesis
  2. Lymphoiesis
37
Q

Leukopoiesis function

A

Innate (Phagocytosis)
Adaptive (Production of antibodies)

38
Q

major function is phagocytosis and destruction of foreign material and microorganism

A

Neutrophil

39
Q

Neutrophil major cytokine

A

G-CSF

40
Q

neutrophil 3 pools for development

A
  1. Stem cell pool
  2. Proliferation pool
  3. Maturation pool
41
Q

what type of myeloblast has fine nuclear chromatin with 2 or 4 visible nucleoli

A

type 1

42
Q

what type of myeloblast has presence of azurophilic granules

A

Type 2

43
Q

type of myeloblast that has darker chromatin and purple cytoplasm

A

Type 3

44
Q

Myeloblast size

A

15-20 um

45
Q

type of granulocyte wherein nucleus are round to oval. Azurophilic granules

A

Promyelocyte

46
Q

type of granulocyte that is primary to secondary neutrophil granules development, lavender-pink

A

Myelocytes

47
Q

type of granulocyte that is no longer capable of cell division, kidney bean shaped and little amount of RNA is present

A

Metamyelocyte

48
Q

tertiary granules aka

A

gelatinase granules

49
Q

type of granulocyte that has no rna and has secretory granules

A

Bands

50
Q

type of granulocyte that has secretory granules

A

segmented neutrophils

51
Q

similar development with neutrophils

A

eosinophils

52
Q

major cytokines of Eosinophils

A

GM-CSF
IL-5
IL-3

53
Q

Eosinophilic promyeloblast has primary granules that has presence of ___

A

Charcot-Leyden Crystals

54
Q

type of eosinophil, secondary granules

A

Eosinophilic myelocyte

55
Q

type of eosinophil that resembles that band in neutrophils development

A

Eosinophilic metamyelocyte

56
Q

type of eosinophil that is bilobed nucleus

A

mature eosinophils

57
Q

true leukocytes mature in bone marrow and circulates in blood

A

basophils

58
Q

major cytokine of MONOCYTE

A

M-CSF

59
Q

type of monocyte that is very rare and difficult to distinguish from myeloblast

A

Monoblasts

60
Q

When monocytes resides on the tissue they differentiate from __

A

Macrophage

61
Q

macrophage has a ___-like chromatin

A

net-like

62
Q

Lymphocyte is divided into 3 major groups

A

T cell
B cell
natural killer cells

63
Q

Lymphocyte adaptive immunity

A

T and B cell

64
Q

Lymphocyte Innate immunity

A

NK cells

65
Q

Lymphocyte type, cytoplasm: dark blue

A

Lymphoblast

66
Q

Lymphocyte type, cytoplasm: moderate dark blue, same or smaller than lymphoblast

A

Prolymphocyte

67
Q

Life span of neutrophil

A

9-10 days

68
Q

eosinophil life span

A

half life: 18 hours

69
Q

basophil life span

A

4.3 days or 12 hours

70
Q

monocyte life span

A

60 hours

71
Q

lymphocyte life span

A

3-4 days but majority for months to years

72
Q

platelets from bone marrow is called

A

megakaryocytes

73
Q

hormone used for development of platelets

A

thrombopoietin

HEMA (4 decks)

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