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HEMA > ERYTHROPOIESIS - MEGAKARYOPOIESIS > Flashcards

ERYTHROPOIESIS - MEGAKARYOPOIESIS Flashcards

1
Q

nucleated RBC precursors are called

A

Erythroblast

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2
Q

erythrocyte precursors develop from two progenitors

A
  1. burst-forming unit-erythroid (large colonies)
  2. colony-forming unit-erythroid (small colony)
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3
Q

it takes __-__ days for precursors to become mature enough to enter the circulation

A

6-7 days

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4
Q

Pronormoblast, Rubriblast, Proerythroblast. Nucleus:

A

8:1, round tooval, containing 1-2 nucleoli

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5
Q

Pronormoblast, Rubriblast, Proerythroblast. Cytoplasm

A

Dark Blue

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6
Q

Pronormoblast, Rubriblast, Proerythroblast. Location

A

Bone marrow

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7
Q

Cellular activity: begins to accumulate necessary for hemoglobin production

A

Pronormoblast, Rubriblast, Proerythroblast

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8
Q

Pronormoblast, Rubriblast, Proerythroblast. Life span

A

slightly more than 24hrs

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9
Q

Basophilic normoblast, Prorubricyte, Basophilic erythroblast. Size

A

12-17 um

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10
Q

Pronormoblast, Rubriblast, Proerythroblast. size

A

14-20 um

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11
Q

Basophilic normoblast, Prorubricyte, Basophilic erythroblast. cytoplasm

A

deeper blue

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12
Q

Basophilic normoblast, Prorubricyte, Basophilic erythroblast. life span

A

slightly more than 24hrs

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13
Q

Cellular activity: detectable hemoglobin synthesis occur

A

Basophilic normoblast, Prorubricyte, Basophilic erythroblast

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14
Q

Polychromatic normoblast, Rubricyte, Polychromatic erythroblast. size

A

10-15 um

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15
Q

Polychromatic normoblast, Rubricyte, Polychromatic erythroblast. nucleus

A

4:1, no nuclei present

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16
Q

Polychromatic normoblast, Rubricyte, Polychromatic erythroblast. cytoplasm

A

gray-blue

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17
Q

cellular activity: capable of undergoing mitosis, hemoglobin synthesis increases

A

Polychromatic normoblast, Rubricyte, Polychromatic erythroblast.

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18
Q

Polychromatic normoblast, Rubricyte, Polychromatic erythroblast. life span

A

approx. 30 hrs

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19
Q

Orthrochromic normoblast, Metaubricyte, Orthrochromic erythroblast. Nucleus

A

1:2, nucleus is completely condensed

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20
Q

Orthrochromic normoblast, Metaubricyte, Orthrochromic erythroblast. cytoplasm

A

salmon pink

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21
Q

Orthrochromic normoblast, Metaubricyte, Orthrochromic erythroblast. life span

A

approx. 48 hrs

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22
Q

Cellular activity: the nucleus is ejected from the cell

A

Orthrochromic normoblast, Metaubricyte, Orthrochromic erythroblast

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23
Q

Polychromatic erythrocyte, Reticulocyte. nucleus

A

no nuclei present

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24
Q

Polychromatic erythrocyte, Reticulocyte. cytoplasm

A

salmon pink, shape is still not biconcave

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25
Polychromatic erythrocyte, Reticulocyte. location
resides in bone marrow for 1-2 days, them moves to the peripheral blood for 1 day before reaching maturity
26
cellular activity: complete hemoglobin production
Polychromatic erythrocyte, Reticulocyte
27
life span: 2-3 days, reside in bone marrow for 1-2 days then moves to peripheral blood for 1 day
Polychromatic erythrocyte, Reticulocyte
28
granulocyte that react with both basic and acid stain
Neutrophil and Basophil
29
granulocyte that react with acid stain only
Eosinophil
30
Erythrocyte cytoplasm
salmon pink, biconcave shape 1/3 central palor
31
glyctoprotein hormone produce in the renal peritubular interstitial cells
erythropoietin
32
produced in the kidney, and acting at a distant location
erythropoietin
33
3 major effects of erythropoietin
1. allowing early release of reticulocytes from the bone marrow 2. preventing apoptotic cell death 3. reducing time needed for cells to mature in the bone marrow
34
programmed cell death
apoptosis
35
cell injury caused by inflammation
necrosis
36
Leukopoiesis is divided into two major categories
1. Myelopoiesis 2. Lymphoiesis
37
Leukopoiesis function
Innate (Phagocytosis) Adaptive (Production of antibodies)
38
major function is phagocytosis and destruction of foreign material and microorganism
Neutrophil
39
Neutrophil major cytokine
G-CSF
40
neutrophil 3 pools for development
1. Stem cell pool 2. Proliferation pool 3. Maturation pool
41
what type of myeloblast has fine nuclear chromatin with 2 or 4 visible nucleoli
type 1
42
what type of myeloblast has presence of azurophilic granules
Type 2
43
type of myeloblast that has darker chromatin and purple cytoplasm
Type 3
44
Myeloblast size
15-20 um
45
type of granulocyte wherein nucleus are round to oval. Azurophilic granules
Promyelocyte
46
type of granulocyte that is primary to secondary neutrophil granules development, lavender-pink
Myelocytes
47
type of granulocyte that is no longer capable of cell division, kidney bean shaped and little amount of RNA is present
Metamyelocyte
48
tertiary granules aka
gelatinase granules
49
type of granulocyte that has no rna and has secretory granules
Bands
50
type of granulocyte that has secretory granules
segmented neutrophils
51
similar development with neutrophils
eosinophils
52
major cytokines of Eosinophils
GM-CSF IL-5 IL-3
53
Eosinophilic promyeloblast has primary granules that has presence of ___
Charcot-Leyden Crystals
54
type of eosinophil, secondary granules
Eosinophilic myelocyte
55
type of eosinophil that resembles that band in neutrophils development
Eosinophilic metamyelocyte
56
type of eosinophil that is bilobed nucleus
mature eosinophils
57
true leukocytes mature in bone marrow and circulates in blood
basophils
58
major cytokine of MONOCYTE
M-CSF
59
type of monocyte that is very rare and difficult to distinguish from myeloblast
Monoblasts
60
When monocytes resides on the tissue they differentiate from __
Macrophage
61
macrophage has a ___-like chromatin
net-like
62
Lymphocyte is divided into 3 major groups
T cell B cell natural killer cells
63
Lymphocyte adaptive immunity
T and B cell
64
Lymphocyte Innate immunity
NK cells
65
Lymphocyte type, cytoplasm: dark blue
Lymphoblast
66
Lymphocyte type, cytoplasm: moderate dark blue, same or smaller than lymphoblast
Prolymphocyte
67
Life span of neutrophil
9-10 days
68
eosinophil life span
half life: 18 hours
69
basophil life span
4.3 days or 12 hours
70
monocyte life span
60 hours
71
lymphocyte life span
3-4 days but majority for months to years
72
platelets from bone marrow is called
megakaryocytes
73
hormone used for development of platelets
thrombopoietin

HEMA (4 decks)

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