Erythropoiesis

Question 1

process of RBC formation

Answer 1

Erythropoiesis

Question 2

total mass of RBCs circulating in the peripheral blood AND the bone marrow RBC precursors

Answer 2

Erythron

Question 3

erythrocytes in the circulation

Answer 3

RBC mass

Question 4

term that describes the dynamics of RBC creation and destruction

Answer 4

Erythrokinetics

Question 5

production of defective erythroid precursor cells

Answer 5

Ineffective erythropoiesis

Question 6

Immature hematopoietic cell that is committed to a cell line but cannot identified morphologically

Answer 6

Progenitor cells

Question 7

Immature hematopoietic cell that is morphological identifiable as belonging to a given cell lines

Answer 7

Precursor cells

Question 8

Earliest marker of Erythroid differentiation;Transferrin receptors

Answer 8

CD71

Question 9

chief stimulatory cytokine for RBCs

Answer 9

Erythropoietin

Question 10

Erythropoietin primary cell source:

Answer 10

Peritubular interstitial cells (Kidneys)

Question 11

Erythropoietin primary target cells

Answer 11

BFU-E, CFU-E

Question 12

EARLIEST committed progenitor

Answer 12

BFU-E

Question 13

From BFU-E to CFU-E

Answer 13

1 week

Question 14

It takes about ______ for CFU-E to become Rubriblast

Answer 14

1 week

Question 15

It takes about ________ days for the BFU-E to mature to an erythrocyte

Answer 15

*It takes about 18 to 21 days for the BFU-E to mature to an erythrocyte

Question 16

What is the name of reticulocyte when stain in WRIGHT stained smear

Answer 16

Polychromatophilic Erythrocytes

Diffusely Basophilic Erythrocytes

Question 17

size of rubriblast?

Answer 17

12 to 19 um

Question 18

Earliest recognizable erythroid precursor

Answer 18

Rubriblast/Pronormoblast

Question 19

N:C ration of Pronormoblast

Answer 19

4:1

Question 20

Prorubricyte
Size:______
N:C ratio:________

Answer 20

Size: 12 to 17 um
N:C ratio 4:1

Question 21

Last stage with a nucleous
a. Rubriblast
b. Prorubricyte
c. Rubricyte
d. Metarubricyte

Answer 21

PRORUBRICYTE (BASOPHILIC NORMOBLAST)

Question 22

1st stage of Hb synthesis

Answer 22

PRORUBRICYTE (BASOPHILIC NORMOBLAST)

Question 23

Rubricyte
Size:_______
N:C ratio_______

Answer 23

Size: 11 to 15 um
Ratio: 1:1

Question 24

Last stage capable of mitosis

Answer 24

RUBRICYTE

Question 25

METARUBRICYTE
Size:________
N:C_____

Answer 25

Size: 8 to 12 um
N:C: 1:2

Question 26

other name of Metarubricyte (clue 7 yon)

Answer 26

1. ORTHOCHROMATIC NORMOBLAST
2. Orthochromatic Erythroblast
3. Late Erythroblast
4. Late normoblast
5. Nucleated RBC (NRBC),
   6.Pyknotic erythroblast
   7.Acidophilic normoblast

Question 27

Last stage with nucleus

Answer 27

METARUBRICYTE

Question 28

Reticulocyte
Size:_____

Answer 28

7-10 um

Question 29

LAST STAGE OF HEMOGLOBIN SYNTHESIS

Answer 29

RETICULOCYTE

Question 30

Reticulocyte spends ______days in the bone marrow and________ day in the peripheral blood before
developing into a mature RBC.

Answer 30

Spends 2 to 3 days in the bone marrow

and1 day in the peripheral blood before
developing into a mature RBC

Question 31

The shape of the reticulocyte is _____
in electron micrographs

Answer 31

irregular

Question 32

Size of mature Erythrocyte

Answer 32

6 to 8 um

Question 33

Thickness of Mature erythrocyte_____

Answer 33

Thickness: 1.5 to 2.5 μm

Question 34

Life span of RBC

Answer 34

120 days

Question 35

Number of erythrocytes produced from
each rubriblast__________

Answer 35

8 to 32

Question 36

Normal ratio of RBCs to WBCs

Answer 36

600:1

Question 37

Normal ratio of RBCs to Platelets

Answer 37

15:1

Question 38

Normal ratio of RBCs to Platelets

Answer 38

15:1