Erythrocyte

Question 1

What is the deficient protein in HEREDITARY SPHEROCYTOSIS

Answer 1

Ankyrin
Band 3
α-Spectrin
β-Spectrin
Protein 4.2

Question 2

Confirmatory test for Hereditary spherocytosis

Answer 2

EMA binding test

Question 3

Defect in proteins that disrupt the horizontal linkages in the protein cytoskeleton; loss of mechanical stability of membrane

a. HS
b. Hereditary elliptocytosis
c. Hereditary pyropoikilocytosis
d. Hereditary ovalocytosis

Answer 3

Hereditary Elliptocytosis

Question 4

Severe defect in spectrin that disrupts horizontal linkages in protein cytoske- leton; severe RBC frag-mentation

a. HS
b. Hereditary elliptocytosis
c. Hereditary pyropoikilocytosis
d. Hereditary ovalocytosis

Answer 4

c. Hereditary pyropoikilocytosis

Question 5

Resistant to malaria

a. HS
b. Hereditary elliptocytosis
c. Hereditary pyropoikilocytosis
d. Hereditary ovalocytosis

Answer 5

d. Hereditary ovalocytosis

Question 6

Autosomal recessive
a. HS
b. Hereditary elliptocytosis
c. Hereditary pyropoikilocytosis
d. Hereditary ovalocytosis

Answer 6

c. Hereditary pyropoikilocytosis

Question 7

Deficient protein is α-Spectrin and β-Spectrin

a. HS
b. Hereditary elliptocytosis
c. Hereditary pyropoikilocytosis
d. Hereditary ovalocytosis

Answer 7

c. Hereditary pyropoikilocytosis

Question 8

HS patients have an increase in the________ value
a. MCV
b. MCH
c. MCHC

Answer 8

c. MCHC

Question 9

RBC Metabolic pathway that is Non-oxidative, anaerobic pathway

Answer 9

Embden-Meyerhof Pathway

Question 10

Major Glycolytic pathway

Answer 10

Embden-Meyerhof Pathway

Question 11

Most common enzyme deficiency of the EMP and is the most common form of hereditary nonspherocytic hemolytic anemia (HNSHA).

Answer 11

PYRUVATE KINASE (PK) DEFICIENCY

Question 12

Confirmatory test for PK deficiency

Answer 12

Quantitative PK assay

Question 13

Hexose Monophosphate Shunt aka __________ & ____________

Answer 13

pentose phosphate pathway or phosphogluconate pathway

Question 14

Aerobically converts glucose to pentose and produces NADPH

Answer 14

Hexose Monophosphate Shunt

Question 15

RBC count reference range for ADULT FEMALE is ________
a. 4.00 to 5.40 X 106/L and 4.00 to 5.40 X 1012/uL
b. 4.00 to 5.40 X 106/uL and 4.00 to 5.40 X 1012/L
c. 4.60 to 6.00 X 106/L and 4.60 to 6.00 X 1012/uL
d. 4.60 to 6.00 X 106/uL and 4.60 to 6.00 X 1012/L

Answer 15

b. 4.00 to 5.40 X 106/uL and 4.00 to 5.40 X 1012/L

Question 16

RBC count Reference range for MALE is ________

a. 4.00 to 5.40 X 106/L and 4.00 to 5.40 X 1012/uL
b. 4.00 to 5.40 X 106/uL and 4.00 to 5.40 X 1012/L
c. 4.60 to 6.00 X 106/L and 4.60 to 6.00 X 1012/uL
d. 4.60 to 6.00 X 106/uL and 4.60 to 6.00 X 1012/L

Answer 16

d. 4.60 to 6.00 X 106/uL and 4.60 to 6.00 X 1012/L

Question 17

Most common enzyme deficiency in the pentose phosphate pathway and is also the most common RBC enzyme defect

Answer 17

GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD) DEFICIENCY

Question 18

Confirmatory test for G6PD

Answer 18

Quantitative G6PD assay

Question 19

What pathway Maintain Iron in the Heme (Hb) in its reduce state (Ferrous/Fe )
a. Embden-Meyerhof Pathway
b. phosphogluconate pathway
c. Rapoport-Luebering Shunt
d. Cytochrome b5 reductase

Answer 19

d. Methemoglobin Reductase Pathway, AKA: Cytochrome b5 reductase

Question 20

For the Production of 2,3 BPG

a. Embden-Meyerhof Pathway
b. phosphogluconate pathway
c. Rapoport-Luebering Shunt
d. Cytochrome b5 reductase

Answer 20

C. Rapoport-Luebering Shunt

Question 21

In Oxygen dissociation curve ⬆️ pH is _______
a. Shift to the Right
b. Shift to the Left
c. Shift to the Top
d. Shit to the bottom

Answer 21

b. Shift to the Left

Question 22

In Oxygen dissociation curve ⬇️ pH is _______

a. Shift to the Right
b. Shift to the Left
c. Shift to the Top
d. Shit to the bottom

Answer 22

a. Shift to the Right

Question 23

Which of the following OXYGEN DISSOCIATION CURVE is INCORRECT
a. Shift to the left: ⬆️ pH, ⬇️ Temperature, ⬇️PCO2
b. Shift to the right: ⬆️ Temperature, ⬆️ PCO2,
c. Shift to the left: ⬇️ 2,3BPG, ⬆️Affinity
d. Shift to the right: ⬇️ PCO2, ⬇️ Affinity

Answer 23

d. Shift to the right: ⬇️ PCO2, ⬇️ Affinity