Erythrocyte Flashcards
What is the deficient protein in HEREDITARY SPHEROCYTOSIS
Ankyrin
Band 3
α-Spectrin
β-Spectrin
Protein 4.2
Confirmatory test for Hereditary spherocytosis
EMA binding test
Defect in proteins that disrupt the horizontal linkages in the protein cytoskeleton; loss of mechanical stability of membrane
a. HS
b. Hereditary elliptocytosis
c. Hereditary pyropoikilocytosis
d. Hereditary ovalocytosis
Hereditary Elliptocytosis
Severe defect in spectrin that disrupts horizontal linkages in protein cytoske- leton; severe RBC frag-mentation
a. HS
b. Hereditary elliptocytosis
c. Hereditary pyropoikilocytosis
d. Hereditary ovalocytosis
c. Hereditary pyropoikilocytosis
Resistant to malaria
a. HS
b. Hereditary elliptocytosis
c. Hereditary pyropoikilocytosis
d. Hereditary ovalocytosis
d. Hereditary ovalocytosis
Autosomal recessive
a. HS
b. Hereditary elliptocytosis
c. Hereditary pyropoikilocytosis
d. Hereditary ovalocytosis
c. Hereditary pyropoikilocytosis
Deficient protein is α-Spectrin and β-Spectrin
a. HS
b. Hereditary elliptocytosis
c. Hereditary pyropoikilocytosis
d. Hereditary ovalocytosis
c. Hereditary pyropoikilocytosis
HS patients have an increase in the________ value
a. MCV
b. MCH
c. MCHC
c. MCHC
RBC Metabolic pathway that is Non-oxidative, anaerobic pathway
Embden-Meyerhof Pathway
Major Glycolytic pathway
Embden-Meyerhof Pathway
Most common enzyme deficiency of the EMP and is the most common form of hereditary nonspherocytic hemolytic anemia (HNSHA).
PYRUVATE KINASE (PK) DEFICIENCY
Confirmatory test for PK deficiency
Quantitative PK assay
Hexose Monophosphate Shunt aka __________ & ____________
pentose phosphate pathway or phosphogluconate pathway
Aerobically converts glucose to pentose and produces NADPH
Hexose Monophosphate Shunt
RBC count reference range for ADULT FEMALE is ________
a. 4.00 to 5.40 X 106/L and 4.00 to 5.40 X 1012/uL
b. 4.00 to 5.40 X 106/uL and 4.00 to 5.40 X 1012/L
c. 4.60 to 6.00 X 106/L and 4.60 to 6.00 X 1012/uL
d. 4.60 to 6.00 X 106/uL and 4.60 to 6.00 X 1012/L
b. 4.00 to 5.40 X 106/uL and 4.00 to 5.40 X 1012/L
RBC count Reference range for MALE is ________
a. 4.00 to 5.40 X 106/L and 4.00 to 5.40 X 1012/uL
b. 4.00 to 5.40 X 106/uL and 4.00 to 5.40 X 1012/L
c. 4.60 to 6.00 X 106/L and 4.60 to 6.00 X 1012/uL
d. 4.60 to 6.00 X 106/uL and 4.60 to 6.00 X 1012/L
d. 4.60 to 6.00 X 106/uL and 4.60 to 6.00 X 1012/L
Most common enzyme deficiency in the pentose phosphate pathway and is also the most common RBC enzyme defect
GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD) DEFICIENCY
Confirmatory test for G6PD
Quantitative G6PD assay
What pathway Maintain Iron in the Heme (Hb) in its reduce state (Ferrous/Fe )
a. Embden-Meyerhof Pathway
b. phosphogluconate pathway
c. Rapoport-Luebering Shunt
d. Cytochrome b5 reductase
d. Methemoglobin Reductase Pathway, AKA: Cytochrome b5 reductase
For the Production of 2,3 BPG
a. Embden-Meyerhof Pathway
b. phosphogluconate pathway
c. Rapoport-Luebering Shunt
d. Cytochrome b5 reductase
C. Rapoport-Luebering Shunt
In Oxygen dissociation curve ⬆️ pH is _______
a. Shift to the Right
b. Shift to the Left
c. Shift to the Top
d. Shit to the bottom
b. Shift to the Left
In Oxygen dissociation curve ⬇️ pH is _______
a. Shift to the Right
b. Shift to the Left
c. Shift to the Top
d. Shit to the bottom
a. Shift to the Right
Which of the following OXYGEN DISSOCIATION CURVE is INCORRECT
a. Shift to the left: ⬆️ pH, ⬇️ Temperature, ⬇️PCO2
b. Shift to the right: ⬆️ Temperature, ⬆️ PCO2,
c. Shift to the left: ⬇️ 2,3BPG, ⬆️Affinity
d. Shift to the right: ⬇️ PCO2, ⬇️ Affinity
d. Shift to the right: ⬇️ PCO2, ⬇️ Affinity
