Erythema multiforme

Question 1

What is erythema multiforme

Answer 1

Erythema multiforme (EM) is typically an acute, self-limiting but often relapsing, mucocutaneous inflammatory condition. It is a hypersensitivity reaction associated with certain infections, vaccinations, and, less commonly, medications.

Question 2

What infections are associated with erythema multiforme?

Answer 2

• HSV
  
  • Mycoplasma
  • CMV

Drug causes

• TNF alpha 
• Anti-malarials Anticonvulsants

Question 3

What is Sx of erythema multiforme?

Answer 3

: erythematous well-defined round lesions on extensor surfaces of peripheries
.
• Evolve at different stages (multiform) into pathognomonic target lesions.
• Minimal mucosal involvement
• Annular erythematous rings with an outer erythematous zone and central blister sandwiching a zone of normal skin tone.

Major: systemic upset, fever, mucosa

Question 4

What is Rx for erythema multiforme?

Answer 4

Self limiting

emollients, topical steroids, analgesia

treat infective cause

Major may need IV steroids