ERECTILE DYSFUNCTION Flashcards
what is erectile dysfunction
persistent inability to attain and maintain erection
what causes erectile dysfuction
- physical or psychological causes
- s/e of drugs
drug tx of erectile dysfunction
1) short or long acting phosphodiesterase type 5 inhibitor
2) intracevernosal, intraurethral or topical alprostadil (medical supervision)
MoA of phosphodiesterase type 5 inhibitor
- increases blood flow to penis
- still requires sexual stimulation
examples of short acting phosphodiesterase type 5 inhibitors
occasional PRN
- avanafil
- sildenafil
- vardenafil
examples of long acting phosphodiesterase type 5 inhibitors
PRN/regular low daily dose to allow for spontaneous activity
- tadalafil
how many doses before pt = classsed as non-responder for erectile dysfunction
6 doses at max dose with sexual dysfunction
phosphodiesterase type 5 inhibitors s/e
- flushing
- dizzy
- nasal congestion
- migraine
phosphodiesterase type 5 inhibitors CI
- takes nitrates
- hypotension
- unstable angina or stroke
- angina during intercourse
- pt who shouldn’t have sexual activity
what is priapism and what to do
- erection lasting longer than 4 hours
- medical attention
phosphodiesterase type 5 inhibitors interactions
- nitrates
- alpha blockers
alprostadil caution
wear condom if partner = child bearing age, pregnant or lactating
which medications cause erectile dysfunction
- Antidepressants
- Antihistamines
- ACE inhibitors
- Cimetidine
- Ketoconazole
- Ranitidine
- Beta blockers
- Chemotherapy drugs
- Opioid
- Spironolactone
- Antipsychotics
- Benzodiazepines
- Diuretics
- Antiarrhythmics
- Anticonvulsant
