Erdman - Monobactams Flashcards
1
Q
What are the monobactams
A
Aztreonam
2
Q
Monobactam activity against gram-positives
A
None
3
Q
Monobactam activity against gram-negatives
A
-HENPECKSSS
-Pseudomonas (resistance has been emerging)
4
Q
Can monobactams penetrate the CNS?
A
Yes only in the presence of inflamed meninges
5
Q
How are monobactams excreted
A
In the urin
6
Q
Monobactam half-life
A
Short
7
Q
Monobactam clinical uses
A
-Infections due to susceptible gram-negative aerobes
-Used in patients with significant penicillin allergies
8
Q
Monobactam adverse effects
A
-GI
-Hypersensitivity: No cross-reactivity with penicillins
