Erdman - Clindamycin

Question 1

What is clindamycin best used for?

Answer 1

-Best for ADA except for treatment of brain abscesses
-Also covers some gram-positive aerobes

Question 2

What is clindamycin derived from?

Answer 2

Lincomycin

Question 3

Clindamycin mechanism of action

Answer 3

Inhibits protein synthesis by binding exclusively to the 50S ribosomal subunit (binds in close proximity to macrolides and synercid)

Question 4

What is clindamycin antibacterial activity?

Answer 4

Bacteriostatic unless in high concentrations against susceptible organisms

Question 5

Clindamycin mechanisms of resistance

Answer 5

-Altered target sites (erm)
-NOT active efflux (mef)

Question 6

Clindamycin gram-positive coverage

Answer 6

-MSSA
-Some CA-MRSA

Question 7

Clindamycin anaerobe coverage

Answer 7

-Best for ADA
-Not used for C. diff

Question 8

Clindamycin distribution

Answer 8

Good distribution able to penetrate bone and has minimal CSF penetration

Question 9

How is clindamycin metabolized

Answer 9

By the liver

Question 10

Is clindamycin removed by hemodialysis?

Answer 10

No

Question 11

Clindamycin clinical uses

Answer 11

-Anaerobic infections outside of the CNS such as pulmonary infections
-Skin and soft tissue infections in pen-allergic patients or patients with infections due to CA-MRSA

Question 12

Clindamycin adverse effects

Answer 12

-GI effects
-Worst inducer of C. diff colitis