Epilepsy Flashcards

1
Q

What are the possible causes of a blackout?

A
Syncope
First seizure
Hypoxic seizure
Concussive seizure
Cardiac arrhythmia
Non-epileptic attack (narcolepsy, migraine etc)
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2
Q

What is the most common cause of fainting?

A

Vasovagal syncope

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3
Q

What symptoms usually occur pre-syncope?

A
Light-headedness
Nausea
Patient is hot 
Sweating
Tinnitus
Tunnel vision
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4
Q

What are the triggers for vasovagal syncope?

A
Prolonged standing
Standing up quickly
Trauma
Venepuncture
Watching/experiencing medical procedures
Micturition
Coughing
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5
Q

What characteristics differentiate syncope from seizure?

A

Syncope-
Upright posture, pallor common, gradual onset, injury rare, incontinence rare, rapid recovery, precipitants common
Seizure-
Any posture, pallor uncommon, sudden onset, injury relatively common, incontinence common, slow recovery, precipitants rare

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6
Q

What is the cause of hypoxic seizures?

A

Occur when individuals are kept upright in a faint- can occur in aircraft, at the dentist or when passers by try to help someone to their feet

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7
Q

What is the cause of concussive seizures?

A

Can occur after any blow to the head

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8
Q

What is the aetiology of non-epileptic attacks?

A

Commoner in women than men
May have a history of other medically unexplained symptoms
May have history of abuse

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9
Q

What are the characteristics of a non-epileptic attack?

A

May resemble a generalised tonic-clonic seizure
May resemble a “swoon”
May involve bizarre movements

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10
Q

How is a first seizure investigated?

A

Blood sugar testing
ECG
Consideration of alcohol and drugs
CT head

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11
Q

What advice should be given to a patient following a first seizure?

A

Information about first seizure clinic
They may need to inform their employer
Enquire about potentially dangerous leisure activities
Explain driving regulations (can drive car after 6 months or HGV/PSV after 5 years if investigations are normal and they have no further events)

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12
Q

What features are suggestive of primary generalised epileptic seizures?

A

History of myoclonic jerks (especially first thing in the morning)
Absences or feeling strange with flickering lights

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13
Q

What features are suggestive of focal onset epileptic seizures?

A

History of “deja vu”
Rising sensation from abdomen
Episodes where look blank with lip-smacking and fiddling of clothes

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14
Q

What are the different kinds of epilepsy as described by ILAE classification?

A
Generalised seizures
Tonic-clonic seizures
Myoclonic seizures
Clonic seizures
Tonic seizures
Atonic seizures
Absence seizures
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15
Q

How is primary generalised epilepsy characterised?

A
No warning of seizures
<25 years old
May have history of absences and myoclonic jerk 
Generalised abnormality on EEG
May have family history
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16
Q

How is focal/partial epilepsy characterised?

A
May get an "aura"
Any age
Simple partial and complex partial seizures can become secondarily generalised
Focal abnormality on EEG
MRI may show cause
17
Q

What investigations can be useful in epilepsy?

A

EEG for primary generalised epilepsies sometimes show sleep disturbance
MRI for patients under 50 with possible focal onset seizures, CT usually adequate to exclude serious causes over this age
Video-telemetry if uncertainty about diagnosis

18
Q

What is the first line treatment for primary generalised epilepsies?

A

Sodium valproate, lamotrigine or levetiracetam

19
Q

What is the first line treatment for partial and secondary generalised seizures?

A

Leveritacetam, lamotrigine or carbamazepine

20
Q

What is the first line treatment for absence seizures?

A

Ethosuximide

21
Q

What is the first and second line treatment for status epilepictus?

A

First line- lorazepam, midazolam (diazepam)

Second line- valproate or phenytoin

22
Q

What is the second line treatment for generalised epilepsy?

A

Topiramate
Zonisamide
Carbamazepine

23
Q

What is the second line treatment for partial seizures?

A
Sodium valproate
Topiramate
Leviteracetam
Gabapentin
Pregabilin
Zonisamide
Lacosamide
Perampanel
Benzodiazepines
24
Q

What is status epilepticus?

A

Prolonger or recurrent tonic-clonic seizures persisting for more than 30 minutes with no recovery period between seizures

25
Q

What is the treatment for status epilepticus?

A

First line- midazolam, lorazepam, diazepam
Second line- phenytoin, valproate
Third line- anaesthesia usually with propofol or thiopentone