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Biostatics/Epidemiology > Epidemiology 10.1-case-control studies and other study designs > Flashcards

Epidemiology 10.1-case-control studies and other study designs Flashcards

1
Q

What is ecolgic study ? how do you study population level?

A

Ecologic study

Descriptive studies of how to categorize communities by exposure and outcome

Population level

•ecologic, aggregate or correlational studies

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2
Q

What is an ecologic study ?

A

To include crude explorations of exposure and disease in which the group (total population, community) is the unit of analysis

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3
Q

What are the stregths of an ecologic study ? what does it evulate ?

A

Strengths

  • quick and inexpensive
  • many populations can be studied
  • Similar and different populations
  • Evaluation of risk factors
  • Sex, ethnic groups, socioeconomic status
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4
Q

How does Ecologic study get there information ?

A

Ecologic study

To use public data on group attributes and disease rates

•Surveillance systems

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5
Q

What are the limitations of a ecologic study ?

A

Ecologic study

Limitations

  • Ecological fallacy
  • Problems with potential confounding variables
  • Limited information
  • Population mobility (migration)
  • Decrease the exposure
  • Masking variable effects
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6
Q

What is ecological fallacy? What is the problem ?

A

Ecological fallacy

  • Association between disease and group attributes may not signify the same association at the individual level
  • Cannot link individual risk with disease causality
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7
Q

What is a case report ? What is it used for ?

A

Case report

  • Detailed report by one or more clinicians of the medical history of a patient.
  • Unusual medical histories
  • Identification of a new disease or adverse exposures
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8
Q

What are the limiations of a case report ?

A

Case report

  • Limitations
  • We cannot used a measure of association
  • Chance(oneperson)
  • Nocomparisongroup
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9
Q

What is case series ? how long does it occur ? What is it used for ?

A

Case series

  • Description of the characteristics of a group of patients with that disease.
  • Usually occur within a short period of time
  • Possible outbreaks
  • New diseases

ebola

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10
Q

What does a case series lack ?

A

Case series

We cannot used a measure of association

•No comparison group

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11
Q

What is a cross sectional study or prevelance study ? What does it do ? How are exposure and dieases determined ? Cases of the diease are ? And what dont we know ?

A

Cross sectional study or Prevalence study

  • Survey a population
  • Exposure and disease are determined simultaneously for each participant
  • Cases of disease are prevalent cases

–Do not know the duration of disease

Gordis,

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12
Q

What is are the three things cross sectional study used for ?

A

Cross sectional study

  • To define a population
  • To determine the presence or absence of exposure for each participant
  • To determine the presence or absence of disease for each participant
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13
Q

What is a cross sectional study used for ?

A

Cross sectional study

•To determine there is an association between exposure and disease

–To calculate the prevalence of disease in participants with exposure and compare it with the prevalence of disease in participants without the exposure

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14
Q

What is the formula for calcualte cross sectional study?

A

Cross sectional study

To calculate the prevalence of exposure in patients with disease and compare the prevalence of exposure in participants without the disease

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15
Q

What are the limitations of a cross sectional study ?

A

Limitations

–Prevalent cases

•Survival

–Not possible temporal relationship

•Simultaneous measures

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16
Q

What is needed to compare a study in case- control study ? What is not possible without a control ?

A

Case-control study

  • To determine the significance of such observations in a group of cases, a comparison or control group is needed.
  • The observations would have been intriguing, but no conclusion is possible without a control group.
17
Q

What is the purpose of a case- control study ? Does it look at incidence or proportion ?

A

Case-control study

To evaluate the possible relationship of an exposure to a certain disease

–Cases (people with that disease)

–Controls (people without that disease)

•To determine that proportion of the cases were exposed and what proportion were not.

18
Q

What is the first and second step in the case-control study ?

A

Case-control study

Gordis,

First step

–Selecting the cases (person with that disease)

–Selecting controls (persons without that disease)

•Second step

–To measure past exposure by interview and by review of medical records

19
Q

How are case control and cohort study differnt ?

A

Case-control study

–Study begins with diseased and nondiseased people

•Cohort study

–Study begins with exposed and nonexposed people

20
Q

Where can cases be selected from ?

A

Selection of cases & controls

•Cases can be selected from

–Hospitals

–Clinic patients

–Registries of patients

21
Q

What is the problem from selecting cases from a single hospital ? What is the problem from getting cases from a tertiary care hospital ?

A

Problems with cases selected from a single hospital

–Results may not be generalizable to all patients with the disease

•Problems with cases from a tertiary care hospital

–Severely ill patients

22
Q

What is incident cases? and what is the problem ?

A

Selection of cases & controls

Incident cases

–Newly diagnosed cases

–Problem with use of incident cases is that we must often wait for new cases to be diagnosed

23
Q

What is prevalent cases ?

A

Selection of cases & controls

Prevalent cases

–Persons with the disease for some time

–Cases have already been diagnosed (larger number of cases)

–Survival

24
Q

Why is a control so important ? Should the control be simialr to the case ? What must the control represent ?

A

Selection of cases & controls

Controls

–Is a major determinant of whether such a conclusion is valid

–Controls should be similar to the cases in all respects other than having the disease

–Representative of all persons without the disease in the population from which the cases are selected

25
Q

Where do the control participants come from ? where are they found ?

A

Selection of cases & controls

Controls

–Nonhospitalized patients living in the community

  • Probability sample of the total population
  • School rosters
  • Service lists
  • Insurance company lists
26
Q

Where else can controls can come from ?

A

Selection of cases & controls

  • Neighbors
  • Best friend

–Hospitalized patients admitted for diseases other than that for which the cases were admitted

•Similar risk factors

27
Q

What can increase the power of the study ? What must the be the same ?

A

Controls of same type

  • Two, three, four controls for each case to increase the power of the study.
  • Similar characteristics between controls
  • Limited cases (rare diseases)

Gordis,

28
Q

What does matching mean in terms of control ? What other matching are there ?

A

Matching

Matching-“process of selecting the controls so that they are similar to the cases in certain characteristics, such as age, race, sex, occupation and income”

  • Group matching
  • Individual matching
29
Q

What are some limitations in the participants ability to recall ?

A

Limitations in Recall

•Information relating to exposure involves collecting data from subjects by interviews

–Ability to recall information

–Limited information

30
Q

What kind of problem can arise from limitation in recall from leabelign the wrong group non-exposed vs exposed ?

A

Limitations in Recall

•If a limitation of recall regarding exposure affects all subjects a misclassification of exposure status may result.

–Some cases or controls who were exposed will be erroneously classified as unexposed

31
Q

What is the problem with the limitations in recall when the wrong group is labled in a study ? (ex. exposed when they werent ?)

A

Underestimate of the true risk between disease and exposure

32
Q

What is a recall bias ? What is differentia recall ?

A

Recall Bias

  • Major problem
  • Differential recall between cases and controls

–Could artifactually suggest an association between cases and controls

•Erroneous conclusions

33
Q

What is a twisn concordance study measure ? What does an adoption study measure ?

A

Study designs

•Twins concordance study-compares the frequency with which both monozygotic twins or both dizygotic twins develop a disease.

–Measures heritability

•Adoption study-compares siblings raised by biologic vs adoption parents

–Measures heritability and influences of environmental factors

Biostatics/Epidemiology (12 decks)

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