Enzymes in Medicine

Question 1

What structure forms the active site which substrates bound to

Answer 1

Teritiary

Question 2

Term given to different forms of the same enzyme which catalyses the same enzyme

Answer 2

Isoenzyme

Question 3

Which structures in enzymes may be slightly different in isoenzymes

Answer 3

Primary and quaternary structure

Question 4

What type of enzyme is regulated by the binding of an effector which can either inhibit or promote enzyme activity

Answer 4

Allosteric Enzyme

Question 5

What class of enzymes removes electrons from one compound and donates it to another

Answer 5

Oxidoreductases

Question 6

List examples of oxidoreductase

Answer 6

Dehydrogenases
Oxygenases
Peroxidases

Question 7

What is the name of Class 1 enzymes

Answer 7

Oxidoreductases

Question 8

What is the name of Class 2 enzymes

Answer 8

Transferases

Question 9

What type of enzyme moves chemical groups between molecules

Answer 9

Transferases

Question 10

True or False, Transferases have 1 substrate that produces 1 product

Answer 10

False, Two substrates that produces Two Products

Question 11

List examples of transferases

Answer 11

Kinases
Aminotransferases
Phosphomutases

Question 12

What is the name Class 3 enzymes

Answer 12

Hydrolases

Question 13

What class of enzymes are responsible for hydrolysis reactions

Answer 13

Hydrolases

Question 14

List examples of Hydrolases

Answer 14

Esterases
Peptidases
Ribonucleases

Question 15

What is the name Class 4 enzymes

Answer 15

Lyases

Question 16

What class of enzymes participates in C-C cleavage or C-N cleavage or formation

Answer 16

Lyases

Question 17

Lyases are involves in the production of which two hormones

Answer 17

Dopamine, Seratonin

Question 18

Give examples of Lyases

Answer 18

Decarboxylase
Synthases
Aldolases

Question 19

What is the name of Class 5 enzymes.

Answer 19

Isomerases

Question 20

What type of enzyme contributes to moving a group or double bond within a molecule

Answer 20

Isomerases

Question 21

True or False, Isomerases do not contribute to stereochemistry

Answer 21

False. Isomerases may change stereochemistry

Question 22

Give examples of Isomerases

Answer 22

Racemases, mutases, epimerases

Question 23

What is the name of Class 6 enzymes

Answer 23

Ligases

Question 24

What type of enzymes require energy to create C-C bonds

Answer 24

Ligases

Question 25

Give examples of Ligases

Answer 25

Synthetases | Carboxylases

Question 26

What keeps the products of fatty acid synthesis from being broken down from Beta oxidation enzymes

Answer 26

Each enzymes are based in different locations

Question 27

Where does fatty acid synthesis occur

Answer 27

Cytosol

Question 28

Where does Beta oxidation occur

Answer 28

Mitochondria

Question 29

Which enzyme is used in diagnosing HIV, Zika and Pernicious Anaemia (intrinsic factor deficiency)

Answer 29

ELISA (enzyme-linked immunosorbent assay)

Question 30

What enzyme is used in diagnosing STI's, ChikV, and cystic fibrosis

Answer 30

PCR

Question 31

What enzyme can be used to diagnose if infectious epidemics has a clonal source

Answer 31

RFLP (restriction fragment length polymorphism)

Question 32

What enzyme can be used to suggest geographical origin of bacteria

Answer 32

RFLP (restriction fragment length polymorphism)

Question 33

Which bodily organ makes enzymes, insulin and glycogen

Answer 33

Pancreas

Question 34

What do elevated levels of amylase & lipase in the blood suggest

Answer 34

Acute Pancreatitis

Question 35

Where can CPK-1 be found

Answer 35

Brain and lungs

Question 36

Where can CPK-2 be found

Answer 36

heart

Question 37

Where can CPK-3 be found

Answer 37

Skeletal muscle

Question 38

What does CPK stand for

Answer 38

Creatine Phosphokinase

Question 39

If CPK-3 is leaked in the blood, what could be the possible diagnosis

Answer 39

Crush Injury Muscle Atrophy Inflammation

Question 40

If CPK-2 is leaked in the blood, what could be the possible diagnosis

Answer 40

Electrical injury Heart Attack Inflammation of the heart

Question 41

If CPK-1 is leaked in the blood, what could be the possible diagnosis

Answer 41

Stroke Seizure Pulmonary Infarction

Question 42

What enzyme is a part of the haem monooxygenases family

Answer 42

Cytochrome P450

Question 43

True or False Cytochrome P450 has exogenous and endogenous substrates

Answer 43

True

Question 44

True or False, Cytochrome P450 cannot be inhibited

Answer 44

False Cytochrome P450 can be inhibited and induced

Question 45

What drug can be used to induce CYP3A4, which is needed in COC metabolism (Unwanted Pregnancies)

Answer 45

Rifampicin

Question 46

What substance can inhibit CYP3A4, which is needed for Warfrin metabolism (Excessive Bleeding)

Answer 46

Grapefruit Juice

Question 47

What is the group name for Dopamine, Seratonin & Adrenaline

Answer 47

Monamine Oxidases

Question 48

What transmitters are involved in emotion, arousal & memory

Answer 48

Monamine Neurotransmitters

Question 49

What type of inhibitors is used to treat depression, anxiety, Alzheimers, Parkinsons

Answer 49

Monoamine Oxidase Inhibitors

Question 50

What type of enzyme inhibitors are used to restore muscle response in Myasthenia Gravis

Answer 50

Anticholinesterases/ Cholinesterase Inhibitors

Question 51

What drug is used to inhibit xanthine oxidase, the main component used in the formation of uric acid in Gout.

Answer 51

Allopurinol