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Cell Biology (1201) > Enzyme Kinetics > Flashcards

Enzyme Kinetics Flashcards

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1
Q

What are the two types of irreversible inhibitions

A

Covalent Bonding

Suicide inhibitors

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2
Q

What are the three types of reversible inhibitions

A

Competitive, Uncompetitive, Non-Competitive

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3
Q

True or False, Km is decreased in the presence of a competitive inhibitor

A

False, it’s increases

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4
Q

True or False, maximal velocity is decreased in the presence of a competitive inhibitor

A

False it is constant

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5
Q

True or False, Non-competitive inhibition occurs when the inhibitor and the substrate binds to the same site on the enzyme

A

False, they bind on different sites

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6
Q

In non-competitive inhibition, Vmax is _______, do to the effects not being overcome by an increase in substrate concentration

A

Decreased

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7
Q

In non-competitive inhibition, Km is _________, due to the the inhibition not affecting the binding of the enzyme-substrate

A

Constant

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8
Q

Where does the inhibitor bind to in uncompetitive inhibition

A

Enzyme-substrate complex

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9
Q

Km and Vm __________ in uncompetitive inhibiton

A

Decreases

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10
Q

True or False, in non-competing inhibition, Inhibitor binds only to the enzyme

A

False, it binds to both enzyme and enzyme-substrate complex

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11
Q

In non-competitive inhibition, Vm ______ while Km ______

A

Decreased, remains the same

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12
Q

Allosteric Enzymes are regulated by ________

A

Effectors

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13
Q

What the names of the two binding sites for allosteric enzymes

A

Active and Allosteric

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14
Q

________ concentration affects allosteric enzymes

A

Substrate

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15
Q

Hb is an example of what type of non-michaelis menten kinetics

A

Cooperativity

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16
Q

What are the two states in a concerted model

A

Tense or relaxed

17
Q

When a ligand binds, it drives the equilibrium towards what state in a concerted model

A

Relax

18
Q

R concentration ________ apparent Km

A

Decreased

19
Q

Inhibitor binds drives equilibrium to _______

A

T

20
Q

T concentration increases _______

A

Km

21
Q

What disease causes a 3-6 month baby to not be able to turn over, sit or crawl

A

Tay-Sachs Disease

22
Q

What are the symptoms of Tay-Sachs disease

A

Seizures hearing loss, immobility

23
Q

What enzyme is absent in Tay-Sachs disease

A

Beta-Hexosaminidase A

24
Q

What is accumulated in Tay Sachs due to the absence of an enzyme

A

GM2 ganglioside

25
Q

True or False, there is no cure for Tay-Sachs disease

A

True

26
Q

What disease cause symptoms of intellectual disability, seizures and mental disorders

A

Phenylketonuria

27
Q

What enzyme is absent to cause Phenylketonuria

A

Phenylalanine Hydroxylase

28
Q

What disease is caused by a decrease of Phenylalanine

A

Phenylketonuria

29
Q

What disease causes symptoms of severe gout, renal problems, poor muscle control

A

Lesch-Nyhan Syndrome

30
Q

What enzyme is inhibited in Lesch Nyhan Syndrome

A

Hypoxanthine-guanine phosphoribosyltransferaee

31
Q

What pathway is affected in Lesch Nyhan syndrome

A

Purine Salvage Pathway

32
Q

What substance is built up in Lesch Nyhan syndrome

A

Uric Acid

33
Q

True or False, there is no cure for Lesch-Nyhan Syndrome

A

True

34
Q

What disease causes symptoms of Developmental Delay, Megaloblastic Anaemia, FTT

A

Hereditary Orotic Aciduria

35
Q

What enzyme is inhibited in Hereditary Orotic Aciduria

A

Unridine Monophosphate Synthase

36
Q

What pathway is affected in Hereditiry Orotic Aciduria

A

Pyrimidine - Urea cycle

37
Q

What can be used to treat Hereditary Orotic Aciduria

A

Uridine Monophosphate/Uridine Triacetate

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