enzymes as catalysts Flashcards
do enzymes affect the equilibrium positiion of a reaction
no
ennzyme action
specifically bind and stabilise the transition state
transition state
reaction intermeditae which has the greatest free energy
how do enzymes reduce the actovation energy
by providing alternative routes
glycogen storage disease
Enzyme deficiency that results in failure of
glycogen to enter transition “phosphorylated” state
what does the catalytic activity of enzymes depend on
presence of small molecules, called cofactors or coenzymes
cofactors
inorganic metal ions
coenzymes
organic molecules
what are tightly bound coenzymes called
prosthetic group
apoenzyme
enzyme without cofactor
enzyme with cofactor
holoenzyme
isoenzyme
isoforms of enzymes, they catalyse the same reaction but have different properties and structure (and sequence)
what are phosphorylation reactions carried out by
protein kinases
zymogens
inactive precursors of enzymes