Enzymes 3 Flashcards

1
Q

The distinguishing feature
of an enzyme-catalyzed
reaction is that it takes
place within the confines
of a pocket on the enzyme
called the

A

active site

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2
Q

provides a specific
environment, customized
by evolution, in
which a given reaction can
occur more rapidly

A

active site

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3
Q

molecule that is bound in the active site and acted upon by the enzyme is called

A

substrate

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4
Q

The surface of the active site is
lined with _______ that bind the substrate
and catalyze its chemical transformation.

A

amino acid residues with
substituent groups

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5
Q

It is also the starting
point for mathematical treatments
that define the kinetic behavior of enzyme-catalyzed reactions and for theoretical
descriptions of enzyme mechanisms.

A

enzyme-substrate complex

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6
Q

central to the action of
enzymes

A

enzyme-substrate complex

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7
Q

The function of a catalyst is to

A

increase the rate of a reaction

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8
Q

True or False: Catalysts do
not affect reaction equilibria.

A

True

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9
Q

True or False: A higher activation energy corresponds to a faster reaction.

A

False; slower reaction

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10
Q

How to increase reaction rate?

A

Increase pressure and temperature

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11
Q

How to lower activation energy (increase reaction rate)

A

adding catalyst

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12
Q

accelerate the interconversion of S and P

A

enzymes

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13
Q

Boltzmann constant

A

k

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14
Q

Planck’s constant

A

h

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15
Q

relationship between the rate constant k and the activation energy is

A

inverse and exponential

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16
Q

traditional analysis of reaction rates

A

steady-state kinetics

17
Q

propose in 1903 that the combination of an enzyme with its substrate molecule to form an ES complex is a necessary step in enzymatic catalysis

A

Victor Henri

18
Q

Where Victor Henri followed his hypothesis

A

Adolphe Wurtz

19
Q

Victor Henri’s idea was expanded into a general theory of enzyme action by

A

Leonor Michaelis
Maud Menten
(1913)

20
Q

postulated that the enzyme first combines reversibly with its substrate to form an enzyme-substrate complex in a relatively fast reversible step

A

Michaelis and Menten

21
Q

rate equation for a one substrate enzyme-catalyzed reaction

A

Michaelis-Menten Equation

22
Q

special case in Michaelis-Menten equation

A

Km = [S] when V0 = 1/2Vmax