Enzymatic Inhibition Flashcards
what is irreversible inhibition?
bind permanently to enzyme, and enzyme must be replaced
what is competitive inhibition?
inhibitor competes with the substrate
what is uncompetitive inhibition?
inhibitor binds the enzyme-substrate complex, but not the enzyme alone
what is noncompetitive inhibition?
inhibitor binds the enzyme or enzyme-substrate complex; slows or stops enzymatic process, and substrate binding is not affected
what is mixed inhibition?
inhibitor binds enzyme or enzyme-substrate complex; affects substrate binding and enzyme function
what happens to the kinetic curve in competitive inhibition?
no change in Vmax, Km moves right
what happens to the kinetic curve in uncompetitive inhibition?
reduces Vmax, Km moves left
what happens to the kinetic curve in noncompetitive inhibition?
reduces Vmax, no change in Km
what happens to the kinetic curve in mixed inhibition?
reduces Vmax, Km moves right
