Enteric Bacteria

Question 1

By definition, Enteric Bacteria are

Answer 1

gram negative, non-spore-forming, facultative anaerobes straight rods that are catalase + and oxidase -, also are glucose fermenters

Question 2

important virulence factors in the gut

Answer 2

encode for pili, used for adhesion and T3SS secretion systems for adhesion, enterotoxins and subverting gut macrophages

Question 3

common pathogenesis of Enterobacteriacea

Answer 3

Organisms reach the M cells of the Peyer’s patch where immune sampling takes place, it is subverted, bacteria reach macrophages which they subvert for their own survival, induce apoptosis then do a backward invasion of the exterior of the gut

Question 4

how enteric bacteria use macrophages

Answer 4

they can use macrophages as Trojan horses for passage to the local ( Y. entercolitica, false appendicitis) and system wide lymph nodes (S.typhi, typhoid fever)

Question 5

how does one prevent an Enterobacteriace infection?

Answer 5

handwashing, water treatment, pasteurization, and cooking, these infections are fecal-oral

Question 6

what’s Hemolytic Uremic Syndrome

Answer 6

mainly affects pediatrics, generally Shigella or EH E.Coli can trigger this condition once it breachs the gut and enters the bloodstream, releasing Shiga toxin, affecting blood vessels, and etc, thrombocytopenia, uremia, and hemolysis, schistocytes smear

Question 7

what’s Reactive arthritis

Answer 7

occurs in pts with the HLA B27 antigen on WBCs, it’s an autoimmune condition triggered by a bacterial infection, leads to Conjunctivitis, Urethritis and Arthritis

Question 8

what are the ICU Bugs, the opportunistic pathogens

Answer 8

Klebsiella, Enterobacter, Serratia, Proteus, Providencia, and Morganella

Question 9

which organisms can cause Reactive Arthritis

Answer 9

Shigella, Salmonella, Yersinia, Campylobacter or Chlamydia,