energy and cellular metabolism Flashcards
phototrophs
energy from sunlight
autotrophs
energy from own source
chemotrophs
energy from chemical reactions
heterotrophs
energy from different sources
polysaccharide» oligosaccharide
salivary amylase
oligosaccharides» disaccharides
pancreatic amylase
disaccharides» monosaccharides
intestinal disaccharidases
metabolism
biochemical modification of chemical compounds in living cells and organisms
catabolic pathways
types?
reactions which break down
degradative
energy producing
oxidative
anabolic pathways
types?
reactions which build up
biosynthetic
energy consuming
reductive
change in gibbs free energy
change in enthalpy - Temp* change in entropy
+ change in G
temp ^
^ [S]
GTP role
protein metabolism
CTP role
lipid biosynthesis
UTP role
carbohydrate metabolism
metabolism stages
- breakdown of complex molecules into simple units
- conversion of simple units into acetyl coA
- ATP production from oxidation of acetyl CoA
3 major pathways in glucose oxidation
glycolysis
citric acid cycle
oxidative phosphorylation
glycolysis
use of carbs as fuel
glucose> pyruvate
embden-mayerhof-parnas pathway
3 stages of glycolysis
investment/priming (glucose > F1, 6-GP)
splitting (»G3P)
energy conservation/ yield (G3P> Pyruvate)
glucose > glucose6phosphate
hexokinase catalysis
glucokinase location
liver
G6P»_space; F6P
conversion of aldopyranose > ketofuranose
glycolysis overall energy gain
2ATP net gain for every glucose
2 ATP used in investment and 4 generated in yield
reasons for tight regulation of metabolic pathways
link supply w demand
to allow response to environmental changes
maintain constant internal environment
to enable different tissues to interact
glycolysis control
rate-limiting enzymes
enzymes at start of pathway
enzymes at branch in pathway (amount/activity of enzyme)
controlling accessibility of enzyme to substrate
how to control activity of enzyme
conformational change
covalent modification
ways to control accessibility of enzyme to substrate
compartmentalisation of enzymes/ substrate