Energy Flashcards

1
Q

What is metabolism broken down into?

A

Catabolism

Anabolism

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2
Q

What is catabolism?

A

Biochemical reaction that breaks down large molecules to release energy

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3
Q

What is anabolism?

A

Biochemical reaction to synthesise new molecules by consuming energy.

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4
Q

What paths does a lipid take to get to the Krebs cycle?

A

Lipid > fatty acids > beta oxidation > acetyl CoA > Krebs cycle

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5
Q

What path does a carbohydrate take to get to the Krebs cycle?

A

Carbohydrates > glucose > glycolysis > pyruvate > acetyl CoA > Krebs cycle

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6
Q

How do proteins get to the Krebs cycle?

A

Protein > amino acid > deamination > (acetyl CoA) > Krebs cycle

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7
Q

What is deamination?

A

Deamination is the elimination of nitrogen through the process of:

Ammonia > urea > urine

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8
Q

Where does the Krebs cycle occur?

A

The mitochondria

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9
Q

How many molecules of ATP are produced in the Krebs cycle?

A

2

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10
Q

What two energy rich electron donor substances are produced in the Krebs cycle?

A

NADH

FADH2

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11
Q

What is the role of NADH And FADH2?

A

These molecules donate electrons to a series of carrier molecules in a sequence of reactions called the electron transport chain.

The energy released from this is used to generate further molecules of ATP

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12
Q

Fill in the blanks

A
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13
Q

What is the electron transport chain?

A

A controlled release of energy

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14
Q

What carrier molecules are involved in the electron transport chain?

A

Cytochromes

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15
Q

Describe the electron transport chain

A
  1. NADH + H+ + FADH2 synthesises ATP
  2. Coenzymes pass high energy electrons through electron carriers, synthesising ATP
  3. The electrons moved from a high energy state to a lower energy state.
  4. Lower energy electrons are passed to oxygen to produce water.
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16
Q

The Krebs cycle and the electron transport chain both require oxygen to produce ATP. What type of respiration is this?

A

Aerobic cellular respiration

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17
Q

How much ATP is yielded in fat metabolism?

A

Each 18C fatty acid yields 146 ATP

Therefore, each molecule of lipid yields 3×146 = 438 ATP.

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18
Q

Is protein breakdown used in normal energy metabolism?

A

Not really

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19
Q

When is protein energy metabolism used?

A
  1. During sustained, intense exercise.
  2. In starvation when carbohydrate and lipid stores have been used up.
20
Q

Why do we need energy?

A
  1. Muscle contraction.
  2. Protein synthesis.
  3. Active transport.
  4. Maintain body temperature.
  5. Replenishing energy stores.
21
Q

What is the anaerobic glucose breakdown?

A

Glucose > Glycolysis > pyruvate > lactate> Pyruvate > glucogenesis > glucose> glycogen (stored)

22
Q

What happens if EI > EE

A

Excess energy is stored as fat.

Subject is in positive energy balance .

23
Q

What happens if EI < EE?

A

Fat stores are mobilised

Subject is in negative energy balance

24
Q

What happens if EI = EE?

A

Subject is an energy balance

25
What is the calculation for energy available from: carbohydrates, fat, protein, alcohol
Carbohydrates - 3.75 kcal/g Fat - 9 kcal/g Protein - 4 kcal/g Alcohol - 7kcal/g
26
What is a healthy BMI range?
18.5 - 24.9 kg/m2
27
What is an underweight BMI range?
Below 18.5
28
What is an overweight BMI range?
Above 24.9
29
What are the health risks of obesity?
1. Cardiovascular disease. 2. Type two diabetes. 3. Some cancers. 4. Problems with weight-bearing joints. 5. Respiratory problems. 6. Psychological.
30
How much energy does the average 25-year-old female and male need?
Female - 2080 kcal/d Male - 2600 kcal/d
31
What is total energy expenditure (TEE)?
The total amount of energy expended per day
32
What are the three components of TEE?
1. Basal metabolic rate. 2. Physical activity. 3. Thermic effect of food.
33
What is basal metabolic rate?
The minimal energy to survive (heart beat, breathing, brain activity, active transport systems) Accounts for 60 to 70% of TEE in average person (~ 1300 - 1600 kcal/day)
34
What is physical activity in terms of TEE?
The energy to move about (including standing activities, occupational activity, fidgeting, etc) Accounts for 15 to 30% of TEE but very variable . Depends on duration and intensity of activities.
35
What is sedentary behaviour a risk factor of?
Cardiovascular disease and Type two diabetes
36
What is the thermic effect of food (dietary induced thermogenesis) based on TEE?
Increased energy expenditure after eating due to energy cost of digesting and absorbing food. Accounts for ~ 10% of TEE Varies, according to composition of diet
37
What factors affect BMR?
1. Body weight 2. Body composition. 3. Age. 4. Gender.
38
How does body weight affect BMR?
Increase in weight results in an increase in BMR due to tissues using more energy
39
How does body composition (ratio of fat/lean tissue) affect BMR?
Fat tissue is less metabolically active than lean tissue. The higher percentage fat the lower the BMR
40
How does age affect BMR?
BMR is highest per KG in childhood (growth) After ~ 18 years old, ~ 2% drop in BMR per decade This is partly due to changes in body composition
41
How does gender affect BMR?
BMR is higher in males because males have a greater muscle mass
42
How does hypothyroid and hyperthyroid affect BMR?
Hypothyroid decreases BMR Hyper thyroid increases BMR
43
Does pregnancy affect BMR?
Yes, pregnancy increases BMR
44
How is the energy cost of different activities measured?
Calorimetry: 1. Direct 2. Indirect
45
How to measure direct calorimetry
Heat given off by subject is measured by temperature changes in water through flowing through calorimeter. It is very accurate , but costly and technically difficult It does not represent real life
46
How does indirect calorimetry work?
Based on the relationship between energy production and oxygen uptake - 95% of all metabolic reactions require oxygen (Krebs cycle and electron transport chain) The more energy required the greater the oxygen uptake Equipment Douglas bag, computerised respirometers