endometrial hyperplasia

Question 1

what is endometrial hyperplasia caused by?

Answer 1

oestrogen which is unopposed by progresterone

Question 2

what is endometrial hyperplasia associated with?

Answer 2

• taking oestrogen unopposed by progesterone
• obesity
• late menopause
• > 35 years old
• current smoker
• nulliparity
• tamoxifen

Question 3

why is tamoxifen a risk factor for endometrial hyperplasia?

Answer 3

has a pro-oestrogen effect on the uterus and bones

also has an anti-oestrogen effect on breast

Question 4

what is endometrial hyperplasia?

Answer 4

abnormal proliferation of the endometrium in excess of the normal proliferation that occurs during the menstrual cycle

Question 5

what is the feature of endometrial hyperplasia?

Answer 5

abnormal vaginal bleeding e.g. IMB

Question 6

what is the mx of simple endometrial hyperplasia without atypia?

Answer 6

high dose progestogens with repeat sampling in 3-4 months

levonorgestrel intra-uterine system may be used

Question 7

what is the mx of endometrial hyperplasia with atypia?

Answer 7

hysterectomy