Endocytosis, Lysosomes and Trafficking*

Question 1

“cell drinking” and its two subcategories?

Answer 1

pinocytosis - non specific. macro and micropinocytosis

Question 2

plasma membrane invaginations

Answer 2

caveolae

Question 3

which charged molecules are taken up faster?

Answer 3

positive charge at neutral pH

Question 4

in pinocytotic vesicles, what protein is associated with it?

Answer 4

caveolin

Question 5

the matrix of endosomes range in what pH

Answer 5

5.5-6.5

Question 6

In receptor mediated endocytosis, what are the specific binding of certain molecules

Answer 6

ligands, ie. LDL

Question 7

what disease is associated with the lack of production for LDLR

Answer 7

hypercholesterolemias

Question 8

when will lysosomes be active?

Answer 8

when they combine with endosomes to become secondary lysosomes

Question 9

heterophagy

Answer 9

digestion of substances imported into a cell from the external environment, e.g., bacteria & foreign material

Question 10

what is the unique marker for lysosomal targeting

Answer 10

Mannose-6-PO4 groups which are added exclusively to the N-linked oligosaccharides of these enzymes within the lumen of the cis-Golgi by a phosphotransferase

Question 11

what are 4 examples of lysosomal storage diseases?

Answer 11

Pompe’s disease, Gaucher’s disease, Tay-Sachs disease and Fabry’s disease