Protein Synthesis and Secretion Flashcards
where are ribosomal proteins synthesized? and then where is it transported to?
synthesized in cytoplasm and transported to nucleus
where does initiator tRNA begin?
methionine, to P site
protein is folded with the help of what?
chaperone
what are the 4 destinations that a protein may go after translation?
cytosol, peroxisome, mitochondrion and nuclear interior
what are the four different functions of the SER
detox of drugs, breakdown of carb (glycogen), synthesis of steroids (endocrine cells) and cholesterol, Ca++ dynamics
where does hydroxylation reaction occur?
SER
describe the signal sequence for co-translational targeting
patch 15 hydrophobic amino acids
proteolysis
cleavage of the signal sequence by signal peptidase
what degrades misfolded proteins in the ER?
proteasome
what mutation results in slight misfolding which leads to its degradation? (example)
CFTA delta 508
in golgi complex, what 3 locations can the protein go to?
lysosome/endosome, plasma membrane and secretory granules
CGN
cis golgi network, AKA ERGIC
what protein transports proteins from ER to CGN?
COP II
what protein transports CGN to ER?
COP I
what protein transports cgn to cis golgi
COP I
