Endocrinology: Pancreatic Hormones

Question 1

What are the actions of insulin?

Answer 1

• Anabolic effects
  1. Glycogen synthesis
  2. TAG synthesis
• Inhibits catabolism
  1. Inhibits glycogenolysis
  2. Inhibits ketogenesis
  3. Inhibits gluconeogenesis
• Stimulates glucose uptake into
  1. Muscle
  2. Adipose tissue

Question 2

List 8 insulin antagonists:

Answer 2

1. Glucagon
2. Cortisol
3. GH
4. Adrenaline
5. Oestrogen
6. Thyroid hormone
7. Prolactin
8. Human placental lactogen (responsible for the insulin resistance of pregnnacy)

Question 3

What is the main target tissue of glucagon?

Answer 3

Liver