Endocrinology Flashcards
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Endocrine System
METABOLISM, GROWTH, FERTILITY AND STRESS RESPONSE
Endocrine System
chemical compounds released by the endocrine glands
hormones
Affects the tissues distant from the site of production
Hormones
cholesterol backbone
STEROIDS
PROTEINS HAVE:
POLYPEPTIDE
ONE MAJOR COMPOSITION
AMINO
Stimulates the pituitary glands and regulate its secretions
HYPOTHALAMUS
releasing hormone are from
HYPOTHALAMUS
stimulates ACTH in the pituitary gland (adenocorticotropic hormone: targets adrenal gland)
CORTICOTROPIN RELEASING HORMONE (CRH)
stimulates gonads (FSH and LH)
Gonadotropin releasing hormone
Thyroid stimulating hormone
THYROTROPIN RELEASING HORMONE
Inhibitor of prolactin
DOPAMINE
Inhibits TSH and GH
Somatostatin
Master gland that distributes comand to other tissues
Pituitary gland
Stimulating hormones are from
PITUITARY GLAND
Anterior Pituitary Gland Hormones
LUTENIZING HORMONE
FSH
TSH
ACTH
GROWTH HORMONE
PROLACTIN
Posterior Pituitary Gland Hormones
Oxytoxin
Vasopressin/ADH/AVP
Dimeric glycoprotein
LH
FSH
TSH
FEEDBACK HORMONE OF LH:
Sex steroids (E2/T)
FEEDBACK HORMONE of FSH:
INHIBIN
FEEDBACK HORMONE OF ACTH
CORTISOL
FEEDBACK HORMONE OF GROWTH HORMONE
IGF-1
Lactations, labor induction and partuition
Pitocin
Maternal nurturing behavior and mother-infant bonding
OXYTOCIN
Receptor location for vasopressin/ADH
ALH and CD
Promote water retention and reabsorption (regulator: osmoreceptors)
ADH/AVP
ADH/Vasopressin increases coagulation factor:
Factor VIII (liver) and vWF (endothelium)
Direct effector hormones
GH and Prolactin
Calcitonin is secreted by
parafollicular cells
Responsible for the removal of excess calcium
Production is triggered by hypercalcemia
Calcitonin
Thyroid hormones are secreted by
follicular cells
T3 other name
Triiodothyronine
T4 other name
Tetraiodothyronin
Major component of thyroid hormones:
Tyrosine (Iodine)
Protein precursor of thyroid hormones are stored in
lumen of thyroid gland
Enzyme for Thyroid hormones
TPO - thyroid peroxidase
Flow of hormones from Hypothalamus to Liver
Hypothalamus -> TRH -> Anterior pituitary gland -> TSH -> Thyroid gland -> T3 and T4 -> Liver -> Release factors
Hypothyroidism diseases: Primary (from thyroid)
Chronic lymphocytic thyroiditis (Hashimotos thyroiditis)
Treatment for toxic goiter - subtotal thyroidectomy or radioactive iodine
Excessive iodine intake
Subacute thyroiditis
Hypothyroidism disease: Secondary (Pituitary gland)
Hypopituitarism
Hypothyroidism diseases: Tertiary
Hypothalmic dysfunction
Affected by the thyroid gland/ direct problem in thyroid gland (↑TSH)
Primary hypothyroidism
autoimmune disorder; autoantibodies targets thyroid gland and inhibits production of T3 and T4
Hashimoto’s thyroiditis
Antibodies present in hashimoto’s thyroiditis
TgAb, thyroglobulin antibodies
TPOAb, thyroid peroxidase antibodies
Secondary hypothyroiditis decreased:
Pituitary gland (↓TSH)
Increased T3 and T4
Thyrotoxicosis
Hyperthyroidism diseases
Grave’s disease
Toxic adenoma
Toxic multinodular goiter
TSH-secreting tumor
Nonhyperthyroidism
Painful thyroidism
Postpartum thyroiditis
Exogenous hormone
Ectopic thyroid tissue
Grave’s disease pathogenic mechanism:
TSHRAb
Nonhyperthyroidism TSH and RAIU levels
Both decreased
Toxic adenoma pathogenic mechanism
Benign nodule
Toxic multinodular goiter pathogenic mechanism
Foci of functional autonomy
TSH secreting tumor pathogenic mechanism
Benign pituitary tumor