Endocrinology Flashcards
67 year old man, proximal muscle weakness, significant ETOH and smoking history. Macrocytosis, abnormal LFTs, elevated TSH and normal T4. Whats the cause of his symptoms?
ETOH excess. Chronic alcohol use can lead to hypothyroidism.
3 months post partum. Tired and amenorrhea, lack of milk production. Suffered from post partum haeamorrhage which required transfusion after delivery. Diagnosis?
Sheehan’s syndrome: hypopituatarism after pregnancy.
37 year old: weight loss, sweating, palpitations, 230/120, HR 115, bounding pulse. What hormone is responsible for her symptoms?
Catecholamines (Pheao)
34 year old with history of thyrotoxicosis. Planning pregnancy- what is the most appropriate treatment?
Thyroidectomy
Man with very large hands and feet and prominant supraorbital ridges, acanthosis nigracans, enlarged thyroid and hepatomegaly. Aside from HTN what condition is commonly associated with acromegaly?
DM
What is Conn syndrome?
Primary hyperaldosteronism due to benign adrenal adenoma
Classic triad of MEN2A
Medullary thyroid cancer, primary hyperparathyroidism, Phaeochroma
MEN 1
Hyperparathyroidism, pituitary adenomas (typically prolactinomas), pancreatic islet cell tumours
66 year old man, polyuria and weight loss. HbA1c is 50 and he is obese. What should be the next investigation?
CT abdo (anyone over 60 presenting with weight loss and new T2DM)
Most common cause of Cushings syndrome?
Iatrogenic
Treatment of primary hyperaldosteronism due to bilateral adrenal disease?
Spironolactone
Sheehan’s syndrome: levels of cortisol and aldosterone?
Low cortisol, normal aldosterone
First line treatment for primary hyperparathyroidism?
Parathyroid surgery
What also might be present in a patient with adrenal hyperfunction (Cushing’s)?
Hirsuitism
First line investigation for Acromegaly?
IGF-1 levels
Medical management of prolactinoma?
Dopamine agonists e.g. bromocriptine
