Endocrine System Flashcards

1
Q

How does the Negative Feedback System/Mechanism work?

A

This mechanism reverses changes that occurred

Brings body back to homeostasis

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2
Q

How does the Positive Feedback System/Mechanism work?

A

This mechanism reinforces changes that occurred

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3
Q

What regulatory hormones does the hypothalamus produce? What organ do these hormones act on?

A

Releasing hormones and Inhibiting hormones

These hormones act on the Anterior Pituitary Gland and tell it to release or inhibit release of hormones

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4
Q

What two hormones are synthesized in the hypothalamus?

A

Antidiuretic hormone

Oxytocin

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5
Q

What gland stores and releases Antidiuretic hormone and Oxytocin?

A

Posterior Pituitary Gland

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6
Q

The Anterior Pituitary Gland is regulated by which gland?

A

Hypothalamus

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7
Q

What are tropic hormones?

A

Hormones that send messages to other glands and tell those glands to release their specific hormones

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8
Q

What hormones are classified as tropic hormones?

A

Thyroid Stimulating Hormone
Adrenocorticotropic Hormone
Follice Stimulating Hormone
Luteinizing Hormone

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9
Q

What hormones come from the Anterior Pituitary Gland?

A
Thyroid Stimulating Hormone 
Adrenocorticotropic Hormone
Follice Stimulating Hormone
Luteinizing Hormone
Growth Hormone
Prolactin
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10
Q

How does Thyroid Stimulating Hormone (TSH) work?

A

Stimulates the thyroid to release thyroid hormones (T3 and T4)

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11
Q

How does Adrenocorticotropic Hormone (ACTH) work?

A

Stimulates the adrenal cortex to release glucocorticoids (cortisol)

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12
Q

If there is a malfunction of the Anterior Pituitary Gland, what will happen with secretion of its hormones?

A

There will either be too little or too much of various hormones released

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13
Q

The Posterior Pituitary Gland is an extension of what?

A

Extension of the hypothalamus

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14
Q

Does the Posterior Pituitary Gland synthesize its hormones?

A

No

It only stores and releases hormones (Antidiuretic Hormone and Oxytocin)

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15
Q

When would increased levels of Adrenocorticotropic Hormone be present in the body?

A

During periods of stress, trauma, infection, illness, etc.

Levels of Adrenocorticotropic Hormone (ACTH) would be increased because this hormone is stimulating the Adrenal Cortex to release glucocorticoids (cortisol)

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16
Q

How does Antidiuretic Hormone (ADH) - also known as Vasopressin) - work?

A

It regulates fluid volume within the body

When released, it tells the kidneys to reabsorb water, thus conserving water within the body

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17
Q

Which endocrine gland can possibly be palpated?

A

Thyroid Gland

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18
Q

What hormone stimulates the thyroid to release T3 and T4?

A

Thyroid Stimulating Hormone

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19
Q

What three hormones come from the thyroid?

A

Triiodothyronine (T3)
Thyroxine (T4)
Calcitonin

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20
Q

What do T3 and T4 do within the body?

A

Regulate cellular respiration of glucose and fatty acids

Control metabolism throughout entire body and all bodily processes

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21
Q

In order for T3 and T4 to be synthesized by the thyroid, what must be in the diet?

A

Protein and Iodine

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22
Q

What does calcitonin do within the body?

A

Inhibits reabsorption of calcium

Lowers serum calcium levels

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23
Q

When is calcitonin stimulated?

A

When serum calcium levels are too high (hypercalcemia)

It will take excess calcium and store it in the bones and teeth

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24
Q

What hormone is produced by the Parathyroid Gland?

A

Parathyroid Hormone (PTH)

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25
What does Parathyroid Hormone (PTH) do?
Raises serum calcium levels: Pulls calcium from bones Encourages small intestine to absorb more calcium Encourages the kidneys to reabsorb more calcium
26
When is Parathyroid Hormone (PTH) secreted?
During hypocalcemia
27
The Adrenal Medulla releases what hormones?
Epinephrine and Norepinephrine
28
What effect do Epinephrine and Norepinephrine have on the body?
Act on alpha one, beta one and beta two receptors Increase the heart rate, increase the force of cardiac contraction, bronchodilation, vasoconstriction of peripheral arteries, vasodilates skeletal muscle arterioles, tells the liver to convert glycogen to glucose for energy
29
When are Epinephrine and Norepinephrine released?
Released during stressful times (flight or fight) to manage stress response and keep body safe
30
The Adrenal Cortex releases what hormones?
It releases corticosteroids, which include: Glucocorticoids (Cortisol) Mineralocorticoids (Aldosterone) Gonadocorticoids (Androgens)
31
What hormones released by the Adrenal Cortex are essential for life?
Mineralocorticoids | Glucocorticoids
32
What tropic hormone is released to promote the release of Cortisol from the Adrenal Cortex?
Adrenocorticotropic Hormone (ACTH)
33
What is the target organ of Mineralocorticoids (Aldosterone)?
Kidneys
34
What is the target organ of Glucocorticoids (Cortisol)?
Many systemic body tissues
35
What does Glucocorticoids (Cortisol) do for the body?
Provides energy sources to the body during stress (because it tells the liver to convert glycogen to glucose)
36
What organ is both an endocrine and exocrine gland?
Pancreas
37
What hormones does the Pancreas synthesize and release?
Insulin | Glucagon
38
What specific cells synthesize insulin?
Beta cells
39
What specific cells synthesize glucagon?
Alpha cells
40
Where do beta and alpha cells live within the Pancreas?
Islet of Langerhans
41
When ____ cells are destroyed, insulin cannot be synthesized
beta
42
When is insulin released by the Pancreas?
When glucose levels are elevated (hyperglycemia)
43
How does insulin work within the body?
It opens the cells and allows glucose to travel inside of the cells The cells can then use glucose for energy
44
Without insulin, what happens to the cells?
They starve. Glucose cannot get inside of the cells and the cells do not have glucose to use as energy
45
When is glucagon released by the Pancreas?
When glucose levels are decreased (hypoglycemia)
46
How does glucagon work within the body?
Glucagon stimulates the liver to convert glycogen to glucose | Glucose is the usable form of energy for the cells
47
What two endocrine disorders can occur if Antidiuretic Hormone isn't regulated properly?
Diabetes Insipidus | Syndrome of Inappropriate Antidiuretic Hormone
48
What is Diabetes Insipidus? What happens during this issue?
Underproduction of Antidiuertic Hormone Unable to conserve water via kidneys Increased urine output, urine not concentrated Urine specific gravity < 1.005
49
What is a priority nursing concern with Diabetes Insipidus? What is a priority nursing intervention?
Concern: Dehydration Intervention: Promote fluids
50
What is Syndrome of Inappropriate Antidiuretic Hormone? What happens during this issue?
Overproduction of Antidiuertic Hormone Conserve too much water via kidneys Decreased urine output, urine extremely concentrated Urine specific gravity >1.030
51
What is a priority nursing concern with Syndrome of Inappropriate Antidiuretic Hormone? What is a priority nursing intervention?
Concern: Fluid overload Intervention: Restrict fluids, monitor respiratory system for breathing complications (pulmonary edema)
52
What is the basic definition of hypothyroidism?
Too little thyroid hormone (T3 and T4) | Metabolic rate slowed
53
What is the basic definition of hyperthyroidism?
Too much thyroid hormone (T3 and T4) | Metabolic rate sped up
54
Describe primary hypothyroidism
Thyroid gland isn't functioning appropriately Thyroid gland is unable to synthesize and release T3 and T4 into circulation Anterior Pituitary Gland is releasing additional Thyroid Stimulating Hormone (TSH) in attempts to stimulate the thyroid gland. (T3 and T4 are low, TSH is high)
55
Describe secondary hypothyroidism
Anterior Pituitary Gland is not working. It is not synthesizing and releasing Thyroid Stimulating Hormone (TSH) Thyroid gland isn't being stimulated, so it cannot release T3 and T4 into circulation (TSH is low thus causing T3 and T4 to be low)
56
Describe primary hyperthyroidism
Thyroid gland isn't functioning appropriately Thyroid gland is over synthesizing and releasing T3 and T4 into circulation Anterior Pituitary Gland is not releasing additional Thyroid Stimulating Hormone (TSH) in attempts to slow the thyroid gland down (T3 and T4 are high, TSH is low)
57
Describe secondary hyperthyroidism
Anterior Pituitary Gland is not working. It is over synthesizing and releasing Thyroid Stimulating Hormone (TSH) Thyroid gland is being over stimulated, so it is releasing additional T3 and T4 into circulation (TSH is high thus causing T3 and T4 to be high)
58
What are some reasons hypothyroidism may occur?
``` Thyroid gland malfunction Anterior Pituitary Gland malfunction (TSH secretion insufficient) Hashimotos Thyroiditis Insufficient iodine in the diet Thyroid gland removed ```
59
List signs and symptoms of hypothyroidism
``` Fatigue Mental Dullness Bradycardia Hypoventilation Cold intolerance Consitpation Weight gain Dry skin and hair Heart failure Hyperlipidemia Myxedema (Coma) ```
60
What are some reasons hyperthyroidism may occur?
Graves Disease | Goiter
61
List signs and symptoms of hyperthyroidism
``` Heat intolerance Tachycardia Palpitations Hypertension Chest Pain Increased Appetite Weight Loss Frequent stools Fatigued, Irritable Nervousness Tremulous Exopthalmos (with Graves) ```
62
What medication is given to treat hypothyroidism?
Levothyroxine (Synthroid)
63
What type of disease is Type One Diabetes Mellitus classified as?
Autoimmune disease Body attacks beta cells (that live within the Islet of Langerhans in the Pancrea) When beta cells are all killed off, insulin can not be synthesized any longer
64
What does a Type One Diabetic patient need to survive?
Exogenous insulin administration daily for life
65
What is the most prevalent form of Diabetes Mellitus?
Type Two
66
Explain what happens within the body in Type Two Diabetes Mellitus
Insulin secretion is impaired: Beta cells are decreased Beta cells aren't as responsive when glucose levels are elevated, therefore they will not release as much insulin as quickly The tissues within the body are less responsive to insulin
67
How can Type Two Diabetes Mellitus be controlled?
Through proper diet and exercise (weight loss) Oral medications Insulin
68
If a patient is diagnosed with pre-diabetes, how will they manage the disease?
Diet, exercise, weight loss | When done properly, they can avoid the diagnosis of Diabetes Mellitus
69
What are acute complications of Diabetes Mellitus? What is most concerning?
Hypoglycemia Hyperglycemia Ketoacidosis Hypoglycemia is the most concerning, it can kill a patient first
70
What can cause hyperglycemia?
``` Stress Illness Food Not enough medications Not adhering to medication regimen ```
71
List the signs and symptoms of hyperglycemia
``` Polyuria Polyphagia Polydipsia Glycosuria Nocturia Ketouria Blurred Vision Fatigue, Lethargy, Headache Abdominal Pain Eventual Coma ```
72
How can hyperglycemia be treated?
Dietary changes Increase physical activity Oral agents Insulin
73
What can cause hypoglycemia?
Undereating Skipping meals Too much insulin Exercise
74
What patient population is at increased risk for hypoglycemia?
Older adults taking beta blockers | Masked signs of hypoglycemia -- this is called Hypoglycemia Unawareness
75
List signs and symptoms of hypoglycemia
``` Hunger Shaking Tremulous Sweating Palpitations Headache Irritable Confusion Eventual Seizures, Coma ```
76
If the nurse suspects a patient is hypoglycemic, what is the first step?
Check the blood sugar! | Always check the blood sugar so a baseline value is obtained
77
When should the nurse initiate the hypoglycemia protocol?
If the blood sugar is less than 70 mg/dL
78
If the patient's blood sugar is less than 70 mg/dL and the patient is alert and oriented, following commands, what should the nurse do?
Administer 15 to 20 g of a fast acting carb: 4-6 ounces of juice or regular soda, 6 to 8 hard candies
79
If the patient's blood sugar is less than 70 mg/dL and the patient is lethargic, unconscious and/or uncooperative, what should the nurse do?
``` Administer Glucagon (SubQ or IM) If there is IV access, give Dextrose ```
80
How does a patient prevent long term complications of Diabetes Mellitus?
``` Control blood sugar Control Hgb A1C Diet Exercise Weight management Adhere to medication regimen ```
81
What macrovascular damages occur with long term Diabetes Mellitus complications?
``` Atherosclerosis Arteriosclerosis HTN Hyperlipidemia Increased risk of having a myocardial infarction or stroke ```
82
What microvascular damages occur with long term Diabetes Mellitus complications?
Retinopathy | Nephropathy
83
What are some long term complications of Diabetes Mellitus?
``` Neuropathy Increased risk for infection Slow/poor wound healing Microvascular complications Macrovascular complications ```