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LS1 Metabolism > Endocrine system > Flashcards

Endocrine system Flashcards

1
Q

What are some key features common to all control systems, including those in the body involved in homeostasis?

A
  1. Communication - NS and endocrine system
  2. Control centre
  3. Receptor
  4. Effectors
  5. Feedback
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2
Q

What is paracrine control?

A

Endocrine control caused by the local release of hormones (rather than into the blood) which act locally

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3
Q

What is autocrine control?

A

Endocrine control caused by a variety of agents which effect the releasing cell itself, not others around it or large distances away from it

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4
Q

What is the afferent branch of the peripheral nervous system?

A

The peripheral nerves that carry signals from the sensory input towards the brain

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5
Q

What is the efferent branch of the peripheral nervous system?

A

The peripheral nerves that carry signals from the brain towards the motor output

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6
Q

What are the two important control centres in the brain for homeostasis?

A
  1. Hypothalamus in the diencephalon

2. Medulla oblongata in the brain stem

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7
Q

What is the role of the control centre in a control system?

A

To determine the reference set point, to analyse the afferent input and determine the appropriate response

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8
Q

The hypothalamus is involved in the control of what system?

A

Endocrine system

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9
Q

Regions of the medulla are involved in the control of what systems?

A

Ventilation -movement of air between lungs&environment

Cardiovascular system

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10
Q

What do body sensors usually consist of?

A

Specialised nerve endings

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11
Q

What is the role of sensors in the body?

A

To detect stimuli such as changes in the environment

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12
Q

What do chemoreceptors respond to?

A

chemical stimuli

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13
Q

What do thermoreceptors respond to?

A

absolute and relative changes to temperature

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14
Q

What do proprioreceptors respond to?

A

Movement and position of body

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15
Q

What do nocireceptors respond to?

A

potentially damaging stimuli and sends signals which are usually detected as pain

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16
Q

What are effectors?

A

Agents that receive outputs from the control centres down efferent pathways and cause a change e.g. sweat glands responding to efferent signals from the control centre in response to high temperature afferent signals form thermoreceptors

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17
Q

What is feedback?

A

When the output (effect) has an effect on the control centre

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18
Q

What is negative feedback?

A

When the output inhibits the function of the control centre and the effector acts to oppose the stimulus

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19
Q

What is the purpose of negative feedback in control systems?

A

It gives them stability by allowing the set point to be controlled within fine limits

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20
Q

What is positive feedback?

A

The stimulus produces a response which tends to increase its effect rather than counteract it. Therefore positive feedback creates a rapid catastrophic change in state

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21
Q

There are not many examples of positive feedback in the human body, give two

A
  1. Blood clotting cascade - change in state of blood from liquid to solid
  2. Ovulation - build up of FSH causes release of an oocyte form a follicle in the ovary
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22
Q

What is meant by biological rhythms?

A

When the set point of a control system varies throughout the day instead of being a fixed steady value

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23
Q

Explain the biological rhythm that cortisol shows and the effect of this on cortisol measurments

A

The levels of cortisol in blood vary throughout the day from a peak at 7am to a trough at 7pm.
Therefore you should always note the time of day that a blood sample was taken for cortisol measurement and repeated measurement should be taken at the same time of day

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24
Q

The menstrual cycles is an example of a biological rhythm. What varies throughout the cycle?

A

A woman’s core body temperature. A sudden increase in body temperature can be used as a marker for ovulation

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25
Q

Where is the “biological clock” of the brain found?

A

Suprachiasmatic nucleus in the hypothalamus

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26
Q

List 4 nucleases in the hypothalamus and their functions

A
  1. Suprachiasmatic nucleus - “biological clock”
  2. Supraoptic nucleus - oxytocin
  3. Paraventricular nucleus - ADH (vasopressin)
  4. Arcuate nucleus - satiety centre
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27
Q

What is a meant by a CNS nucleus?

A

A cluster of neurones in the brain

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28
Q

What is meant by human’s “natural diurnal cycle”?

A

We keep on a 24 hr 11min cycle maintained by keys in the environment (Zeitgebers)

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29
Q

What is the cause of jet-lag?

A

A mismatch between environmental keys and our “body clocks”

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30
Q

What hormone is involved in setting the biological clock?

A

Melatonin released from the pineal gland in the brain

31
Q

What are the three main body compartments that hold body water?

A
  1. Intracellular fluid
  2. Extracellular fluid
  3. Blood plasma (70kg male - approx. 4.6l)
32
Q

Define osmolality

A

The number of osmole per Kg of solution

33
Q

Define osmolarity

A

The number of osmoles per Litre of solution

34
Q

Define an osmole

A

The amount of substance that dissociates in solution to form one mole of OSMOTICALLY ACTIVE PARTICLES

35
Q

What detects the osmotic pressure and sodium ion concentration of blood plasma?

A

Osmoreceptors in the hypothalamus (supraoptic and paraventricular nuclei)

36
Q

What effects do the osmoreceptors in the paraventricular and supraoptic nuclei have?

A

The influence feelings of thirst and release the hormone ADH from the posterior pituitary

37
Q

What effect does ADH have on the body?

A

ADH increases the permeability of collecting duct to water and therefore increases the reabsorption of water in the kidneys from urine into blood. This makes urine more concentrated and decreases the loss of water into urine.

38
Q

What is the effect of high blood osmality on the osmoreceptors in the hypothalamus?

A

Hypertonic blood - therefore increase ADH secretion and create feeling of thirst

39
Q

What is the effect of low blood osmality on the osmoreceptors in the hypothalamus?

A

Hypotonic blood - therefore decrease ADH secretion and do not generate feeling of thirst

40
Q

A target cell for a hormone will produce a response when what occurs?

A

Normally when a CHANGE in concentration of the hormone occurs

41
Q

List the four categories of chemical type of hormones

A
  1. Peptide/polypeptide (largest group)
  2. Glycoprotein
  3. Amino acid derivatives (amines)
  4. Steroid
42
Q

What type of hormones are insulin, glucagon, growth hormone and placental lactogen?

A

Peptide/ polypeptide hormones (largest group)

43
Q

What type of hormones are LH, FSH and TSH?

A

Glycoprotein hormones

44
Q

What type of hormones are adrenaline (a catecholamine) and thyroid hormones (thyroxine and triiodothyronine)

A

Amino acid derivatives (amines)

45
Q

What type of hormones are these cholesterol-derived hormones: cortisol, aldosterone, testosterone and oestrogen?

A

Steroid

46
Q

What is the difference in storage between polypeptide & catecholamines and steroid hormone endocrine cells?

A

Polypeptide and catecholamine producing cells normally store their hormones in vesicles within their cells, prior to secretion.
Steroid hormone producing cells normally store the precursor, cholesterol, as cholesterol esters in the form of lipid droplets.

47
Q

The thyroid gland is an exception to polypeptide, catecholamine and steroid hormone storage. Where does the thyroid gland store its main hormone?

A

Extracellulary in the form of protein colloid

48
Q

Which categories of hormones are relatively hydrophilic and are transported in the bloodstream dissolved in the blood plasma?

A

Polypeptide hormones, glycoproteins and adrenaline

49
Q

Which categories of hormones are relatively hydrophobic and are transported in the bloodstream bound to specialised transport proteins?

A

Steroid hormones and thyroid hormones

50
Q

Generally, the effect that a hormone has on its target cell depends on its concentration in the bloodstream. How does this differ when considering steroid hormones and thyroid hormones?

A

These hormones bind specifically or non-specifically to proteins in the blood and in their case it is the concentration of unbound or “free hormone” that matters

51
Q

How are thyroid hormones transported in the blood?

A

~75% bound to thyronine binding globulin (TBG)

~25% non-specifically to other proteins , such as albumin

52
Q

Excess secretion of which hormones produces acromegaly (characteristic changes in the shape of the face and body and other metabolic effects)?

A

growth hormone

53
Q

How is the rate of secretion of a hormone normally controlled?

A

negative feedback

54
Q

Pancreatic beta-cells secrete insulin in direct response to what?

A

Blood glucose levels rising above 5mM

55
Q

Define tropic hormones

A

Hormones that have other endocrine glands as their targets

56
Q

Define trophic hormones

A

Hormones that stimulate growth in the target tissue

57
Q

Where are the majority of tropic hormones secreted from?

A

Anterior pituitary

58
Q

Name the six main hormones that the anterior pituitary secretes?

A

FSH - follicle stimulating hormone (as below)
LH - lutenising hormone (affects ovary&testis function)
TSH
ACTH - adrenocorticotropic hormone
Growth hormone - affects metabolism
Prolactin - affects breast development and milk production

59
Q

List the tropic hormones of the anterior pituitary

A

TSH
ACTH
LH
FSH

60
Q

In addition to the action of negative feedback, how can the secretion of the anterior pituitary glands be controlled?

A

By releasing or inhibiting hormones

61
Q

Where do releasing or inhibiting hormones come from and how do they affect the secretion of anterior pituitary hormones?

A

They originate from nerve cells in the hypothalamus and travel to the gland via specialised blood vessels known as the hypophyseal portal vessels. This allows the brain to control hormones secretion and explains how hormone secretion can change during stress.

62
Q

List 4 examples of releasing or inhibiting hormones

A

Thyrotropin releasing hormone (TRH) - releasing
Corcticotropin releasing hormone (CRH) - releasing
Somatotropin releasing hormone (SRH) - GH release
Somatostatin - inhibits GH release

63
Q

Where do lipophilic hormones bind to their receptors?

A

Cytoplasm and/ or nucleus of target cells

64
Q

Where do hydrophilic hormones bind to their receptors?

A

Receptors on the plasma membrane of target cells

65
Q

What can binding of hormones to receptors trigger in the target cell?

A
  1. Activity of enzymes or proteins

2. Expression of genes

66
Q

When hormones bind to receptors on the cell surface, what is often released inside the cell?

A

A second messenger e.g. cAMP, cGMP, Ca2+, IP3 and DAG

67
Q

Hormones that create a quick response (seconds-minutes) often work by…

A

Altering the activity of functional proteins (enzymes, membrane transport proteins) involved in the response mechanism

68
Q

Hormones that create a response over a longer time period (minutes-hours, and may even work after the hormone concentration has returned to normal) work by…

A

changing the rate of gene expression in target cells

69
Q

Where does hormone inactivation occur?

A

Kidneys, liver and sometimes target tissues

70
Q

How are steroid hormones inactivated?

A

By a small change in their chemical structure which makes them more hydrophilic so they can be excreted in urine or bile

71
Q

How are protein hormones inactivated?

A

They undergo more extensive chemical changes and are degraded to amino acids that are reused for protein synthesis

72
Q

What can cause disorder of the endocrine system that can cause clinical consequences?

A
  1. Changes in the endocrine tissues -> under/over-secretion of hormones or structurally abnormal and less effective hormones
  2. The responsiveness of endocrine tissue may be altered by the presence, in the circulation, of abnormal proteins such as antibodies
  3. The physiologically effective concentration of hormone in circulation may be reduced by binding to circulating proteins
  4. There may be changes in the responsiveness of target tissue to hormones resulting from changes to receptors and/or post-receptor events
73
Q

Describe the two ways that negative feedback occurs on the hypothalamus-pituitary-adrenal (HPA) axis

A
  1. ACTH inhibits release of CRH

2. Cortisol inhibits release of CRH from hypothalamus and ACTH from anterior pituitary

74
Q

What triggers the release of CRH?

A

Stress (e.g. pain, fever, hypoglycaemia, low blood pressure)

LS1 Metabolism (18 decks)

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