Alcohol metabolism Flashcards
1
Q
A 55 year old male with alcohol dependence is offered treatment with disulfiram to help him stop drinking. Which is the mechanism of disulfiram?
A
Inhibits the enzyme aldehyde dehydrogenase which converts:
acetaldehyde + NAD+ –> acetate + NADH
This causes build-up of acetaldehyde, the chemical responsible for the feeling of ‘hang-overs’
