Endocrine System Flashcards

1
Q

A system of glands and cells that secrete hormones to regulate and integrate body systems

A

Endocrine System

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2
Q

The endocrine system is a _________.

A

Control system

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3
Q

Endocrine Glands Function

A

Secrete substances into the blood in response to a stimuli

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4
Q

What are hormones?

A

Chemical Messengers (a.k.a mediator molecules)

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5
Q

How do hormones have access to the body cells?

A

Release into interstitial fluid, which then enter the bloodstream, which then circulate to the body

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6
Q

Where are hormones released? How does this connect with where it regulates activity?

A

One part of the body to regulate activity in another

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7
Q

To deliver the hormone message (function), the hormones ____..

A

bind to receptors on the cell membrane of target cells/organs

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8
Q

Explain upregulation & downregulation

A

Upregulation:
-Increasing the target cell receptors due to a lack of circulating hormone
-This increases sensitivity to this hormone
Downregulation:
-Decrease in target cell receptors due to an excess of circulating hormone
-This decreases sensitivity to the hormone

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9
Q

Normally, most hormones are present in the body at all times (usually in small amounts). When will these levels fluctuate?

A

When there is a demand on normal body rhythms

  • Environment
  • Stress
  • Inflammation
  • Pathologies
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10
Q

When are normal rhythms absent?

A

-Disease States

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11
Q

What is secretion controlled by?

A
  1. Nervous System
  2. Chemical changes in blood
  3. Other hormones
  4. Managed through negative feedback loops
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12
Q

Primary Endocrine Glands

A
  1. Pituitary
  2. Thyroid
  3. Parathyroid
  4. Adrenal
  5. Pineal
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13
Q

Other organs that secrete hormones

A
  • Hypothalamus
  • Thymus
  • Ovaries/Testes
  • Pancreas
  • Kidneys
  • Stomach & small intestine
  • Heart
  • Adipose Tissue
  • Placenta
  • Liver
  • Skin
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14
Q

Two things that regulate all aspects of growth, development, metabolism, and homeostasis

A

Hypothalamus and Pituitary Gland

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15
Q

Major integrating centre between the nervous and endocrine systems

A

Hypothalamus

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16
Q

Hormonally, the hypothalamus regulates the synthesis and release of the ____________

A

anterior pituitary hormones

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17
Q

Neurologically, the hypothalamus regulates the synthesis and release of the ____________

A

posterior pituitary hormones

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18
Q

A.k.a Pituitary

A

Hypophysis

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19
Q

Pituitary located/Description

A
  • Sits in the sella turcica of the sphenoid.

- 2 Lobes, Small gland

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20
Q

Hormones of the Anterior Pituitary Gland

A
  1. Human Growth Hormone (hGH)
  2. Thyroid Stimulating Hormone (TSH)
  3. Adrenocorticotropic Hormone (ACTH)
  4. Luteinizing Hormone (LH)
  5. Follicle Stimulating Hormone (FSH)
  6. Prolactin (PRL)
  7. Melanocyte Stimulating Hormone (MSH)
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21
Q

Describe the Human Growth Hormone (hGH)

A
  • Stimulates Tissue Growth
  • Promotes Healing and Tissue Repair
  • Increases Use of Lipids for Energy
  • Decreases Cellular Uptake of Glucose/Elevates Blood Glucose Levels
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22
Q

When is hGH released?

A

In bursts, every few hours

23
Q

What will promote the release of hGH?

A
  • Hypoglycemia
  • Increased SyNS
  • Other hormones (glucagon, cortisol, insulin, estrogen)
24
Q

Factors that will inhibit releasing hGH

A
  • Hyperglycemia
  • REM sleep
  • Obesity
  • Low levels of thyroid hormones
  • High levels of hGH in blood
25
Q

Describe Thyroid Stimulating Hormone (TSH)

A
  • Stimulates the release of thyroid hormones by the thyroid gland
  • Dependent on level of thyroid hormones in blood
26
Q

Describe Adrenocorticotropic Hormone (ACTH)

A
  • Stimulates the release of cortisol from the adrenal glands

- Release increases with stress stimuli and macrophage activity

27
Q

Describe Luteinizing Hormone (LH)

A

Females: Triggers ovulation
Males: Stimulates Testes to release testosterone

28
Q

Describe Follicle Stimulating Hormone (FSH)

A

Females: Triggers ovarian follicle development
Males: Triggers sperm production in the testes

29
Q

Describe Prolactin (PRL)

A

Initiates and maintains milk production in the mammary glands

30
Q

Hormones of the Posterior Pituitary Gland

A
  1. Oxytocin

2. Antidiuretic Hormone (ADH) (Vasopressin)

31
Q

Describe Oxytocin

A
  • During delivery, it enhances smooth mm contraction of the uterus
  • Post-partum, stimulates milk ejection
32
Q

Describe ADH

A
  • Decrease urine production

- Causes arteriolar vasoconstriction

33
Q

Factors that promotes release of ADH

A
  • Dehydration
  • Pain/anxiety/stress/trauma
  • Nicotine
  • Some medication
34
Q

Factors that will inhibit the release of ADH

A
  • Increase blood volume

- Alcohol

35
Q

The Thyroid Gland is inferior to the ___

A

Larynx

36
Q

What does the thyroid produce?

A

Thyroid Hormones and Calcitonin

37
Q

What is the thyroid controlled by?

A

The hypothalamus-pituitary

38
Q

Function of thyroid hormones

A
  1. Increase base metabolic rate
  2. Maintain body temp
  3. Stimulate protein synthesis
  4. Increase use of glucose and lipids to generate ATP
  5. Enhance the actions of norepinephrine
  6. w/ hGH and insulin, body growth accelerates
39
Q

Describe Calcitonin

A

-Decrease blood calcium levels by inhibiting osteoclast activity

40
Q

Where is the Parathyroid Gland located?

A

Posterior aspect of the thyroid gland

41
Q

Parathyroid Gland secretes…

A

Parathyroid Hormone (PTH)

  • Increase blood calcium, magnesium, and phosphate levels by increasing the number and activity of osteoclasts
  • Works with kidneys to decrese their secretion of calcium and magnesium and to promote the formation of calcitriol
42
Q

What is calcitriol?

A

Active form of Vitamin D

43
Q

Two parts of the Adrenal Gland

A
  1. Adrenal Cortex

2. Adrenal Medulla

44
Q

Adrenal Cortex secretes…

A
  1. Aldosterone
  2. Cortisol
  3. Androgens
45
Q

Adrenal Medulla secretes…

A
  1. Epinephrine
  2. Norepinephrine
    (same thing–adrenaline)
46
Q

Describe Aldosterone

A
  • Regulates sodium and potassium levels
  • Helps regulate BP/BV
  • Helps elimination of H+ (acid)
  • Stimulates the kidneys to reabsorb sodium and water and stimulate arteriolar smooth mm contraction
47
Q

When is Aldosterone Released?

A

In response to dehydration, sodium deficiency, hemorrhage

48
Q

Describe Cortisol

A

It is the “Stress Hormone”

Secreting while stressed

49
Q

Describe Androgens

A

During Puberty: stimulate axillary and pubic hair growth
Males (post-pube) weak
Females (post-pube) function in libido and are converted into estrogens

50
Q

Describe Adrenal Medulla

A
  • Produce Norepinephrine/epinephrine
  • both are released during stress and excercise
  • Increase the SyNS response
51
Q

Describe the Pineal gland

A
  • secretes melatonin to regulate sleep cycles

- increase secretion in darkness, decrease secretion in sunlight

52
Q

Describe the Thymus

A

Promotes the maturation of T-cells

53
Q

Describe the pancrease

A
-located in the curve of the duodenum 
Pancreatic Islets (islets of langerhans) secrete:
-Glucagon
-Insulin
-Somatostatin