Endocrine Pharm Flashcards
what is the potency of hydrocortisone
- 1
what is the potency of prednisone
- 3.5
what do you use to replace glucocorticoids
- hydrocortisone
- prednisone
what do you use to replace mineralocorticoids
- fludrocortisone
which drugs are glucocorticoids antagonists
- mifepristone
which drugs are somatostatin analogs used to inhibit ACTH and GH secretion
- pasireotide
which drugs are glucocorticoid synthesis inhibitors
- ketoconazole
- aminoglutethimide
why do you treat hyperprolactinemia with hypercortisolism
- hyperprolactinemia often goes hand in hand with hypercortisolism
MOA of pasireotide
- inhibit release of GH from pituitary gland
MOA of ketoconazole
- inhibit synthesis of cortisol
MOA of aminoglutethimide
- inhibit synthesis of cortisol
side effects of ketoconazole
- gynecomastia
- decrease libido
- impotence
why does ketoconazole react with other drugs
what does this cause
- inhibits CYP3A4
- can’t metabolize the drug
- increased toxicities
MOA of mifepristone
- binds GC receptor and inhibits cortisol binding
mifepristone pregnancy category
why
- X
- induces abortion
how do we treat primary hyperaldosteronism
what are they
- aldosterone antagonists
- spironolactone
- eplerenone
treatments for secondary hypertension due to renovascular cause
- ACEi (-pril)
- ARBS (-artan)
MOA of bisphosphonates
do we use them for mild or severe osteoporosis
- bind to bone
- cause osteoclasts to die by apoptosis
- mild
examples of bisphosphonates
which are oral and which are IV
- alendronate (oral)
- risedonrate (oral)
- ibandronate (oral)
- zoledronate (IV)
toxicities of bisphosphonates
how do we give to patient
- esophagitis (oral only)
- osteonecrosis of the jaw (more common in IV)
- on an empty stomach with lots of water
- patients should remain upright for an hour after ingestion
MOA of raloxifine
do we use them for mild or severe osteoporosis
toxicities
- selective estrogen receptor modulator
- estrogen agonist in bone reversing osteoporosis
- mild
- VTE/stroke
MOA of the parathyroid analogs
examples of these drugs
- do we use them for mild or severe osteoporosis
- in low intermittent doses stimulates osteoblasts
- teriparatide
- abaloparatide
- severe
MOA of Denosumab
do we use them for mild or severe osteoporosis
- inhibits activation of osteoclasts by blocking RANKL
- severe
treatment for hypothyroidism
which one is preferred and why
- levothyroxine/T4 - preferred dude to longer half life
- liothyronine/T3