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Endo > Anterior Pituitary Module > Flashcards

Anterior Pituitary Module Flashcards

1
Q

clinical name of CRH

A
  • corticorelin
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2
Q

clinical name of TRH

A
  • protorelin
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3
Q

do we really use TRH levels in clinical practice?

why

A
  • no

- TSH and thyroid hormone assays more reliable

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4
Q

what hormone does FSH help produce

A
  • estrogen secretion
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5
Q

rise in LH triggers

A
  • ovulation
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6
Q

what hormone does LH help produce

A
  • testosterone
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7
Q

importance of GnRH clinically

A
  • induces ovulation or spermatogenesis in people with hypothalamic disorders
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8
Q

importance of GnRH superagonists and antagonists clinically

A
  • delay puberty in precocious puberty
  • prevent ovulation
  • suppress sex-steroid dependent tumors
  • control estrogen dependent uterine diseases
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9
Q

what produces IGF-1 after stimulation by growth hormone

A
  • the liver
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10
Q

clinical use of somatostatin analogs

A
  • treatment of excess secretion of growth hormone, insulin, TSH, VIP
  • reduction of GI motility
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11
Q

what hormone from the hypothalamus stimulates prolactin release

in which condition will it be high

does prolactin have a true releasing factor

A
  • TRH (will be high in hypothyroidism)

- no true releasing factor

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12
Q

prolactin and dopamine relationship

A
  • prolactin increases dopamine synthesis
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13
Q

why do we use dopamine agonists in prolactin secreting tumors

A
  • decrease serum prolactin

- shrink tumor size

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14
Q

the diagnoses of ADH excess and deficiency focus on

A
  • serum/urine sodium and osmolality
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15
Q

what stimulates growth hormone secretion

A
  • sleep
  • fasting
  • stress
  • exercise
  • hypoglycemia
  • amino acids
  • alpha adrenergic system
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16
Q

what inhibits growth hormone secretion

A
  • malnutrition
  • illness
  • hyperglycemia
  • cortisol
  • beta adrenergic system
17
Q

between growth hormone and IGF-1 which has the longer half life

A
  • IGF-1
18
Q

what happens to growth hormone in a normal person without growth hormone excess if you give them glucose

A
  • growth hormone level decreases
19
Q

what happens to growth hormone in a normal person without growth hormone deficiency if you give them insulin

what do we use this to test

A
  • growth hormone level rises

- GH deficiency

20
Q

in a primary disorder, what is dysfunctional

A
  • the endocrine gland itself
21
Q

in a secondary disorder, what is the problem

A
  • endocrine gland is fine

- received too little or too much tropic hormone from the pituitary

22
Q

anterior pituitary hormones are produced where

posterior pituitary hormones are produced where

A
  • anterior pituitary

- hypothalamus

23
Q

function of ACTH

A
  • stimulates adrenal gland to release cortisol (stress hormone)
24
Q

LH and FSH inhibited by

A
  • prolactin (through GnRH inhibition)
  • estradiol
  • testosterone
  • inhibin

Endo (10 decks)

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