Anterior Pituitary Module Flashcards
clinical name of CRH
- corticorelin
clinical name of TRH
- protorelin
do we really use TRH levels in clinical practice?
why
- no
- TSH and thyroid hormone assays more reliable
what hormone does FSH help produce
- estrogen secretion
rise in LH triggers
- ovulation
what hormone does LH help produce
- testosterone
importance of GnRH clinically
- induces ovulation or spermatogenesis in people with hypothalamic disorders
importance of GnRH superagonists and antagonists clinically
- delay puberty in precocious puberty
- prevent ovulation
- suppress sex-steroid dependent tumors
- control estrogen dependent uterine diseases
what produces IGF-1 after stimulation by growth hormone
- the liver
clinical use of somatostatin analogs
- treatment of excess secretion of growth hormone, insulin, TSH, VIP
- reduction of GI motility
what hormone from the hypothalamus stimulates prolactin release
in which condition will it be high
does prolactin have a true releasing factor
- TRH (will be high in hypothyroidism)
- no true releasing factor
prolactin and dopamine relationship
- prolactin increases dopamine synthesis
why do we use dopamine agonists in prolactin secreting tumors
- decrease serum prolactin
- shrink tumor size
the diagnoses of ADH excess and deficiency focus on
- serum/urine sodium and osmolality
what stimulates growth hormone secretion
- sleep
- fasting
- stress
- exercise
- hypoglycemia
- amino acids
- alpha adrenergic system
what inhibits growth hormone secretion
- malnutrition
- illness
- hyperglycemia
- cortisol
- beta adrenergic system
between growth hormone and IGF-1 which has the longer half life
- IGF-1
what happens to growth hormone in a normal person without growth hormone excess if you give them glucose
- growth hormone level decreases
what happens to growth hormone in a normal person without growth hormone deficiency if you give them insulin
what do we use this to test
- growth hormone level rises
- GH deficiency
in a primary disorder, what is dysfunctional
- the endocrine gland itself
in a secondary disorder, what is the problem
- endocrine gland is fine
- received too little or too much tropic hormone from the pituitary
anterior pituitary hormones are produced where
posterior pituitary hormones are produced where
- anterior pituitary
- hypothalamus
function of ACTH
- stimulates adrenal gland to release cortisol (stress hormone)
LH and FSH inhibited by
- prolactin (through GnRH inhibition)
- estradiol
- testosterone
- inhibin
