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Step 1 > Endocrine Pharm > Flashcards

Endocrine Pharm Flashcards

0
Q

Lispro, aspart, glulisine MOA

A

Insulin rapid acting

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1
Q

Diabetes drug types

A 
Insulin (rapid, short, intermediate, long)
Biguanides
Sulfonylureas
Glitazones / thiazilidinediones
Alpha - glycosidase inhibitors
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3
Q

Regular insuline MOA

A

Short acting

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4
Q

NPH

A

Intermediate acting insulin

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5
Q

Glargine, Detemir

A

Lon acting insulin

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6
Q

Metformin

A

Biguanides

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7
Q

Metformin MOA

A

Uknown
Decrease gluconeogensis
Increase glycolysis
Increase peripheral glucose intake / insulin sensitivity

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8
Q

Metformin SEs

A 
GI upset (most common)
Lactic acidosis (most serious >> contraindicated in renal failure)
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9
Q

Tolbutamide, Chlorpropramide

A

1st Gen Sulfonylureas

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10
Q

Glyburide, Glimepride, Glipizide

A

2nd Gen Sufonylureas

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11
Q

Sulfonylureas MOA

A

Close K channel in Beta cells&raquo_space;> depolarize&raquo_space; calcium influx&raquo_space; insulin release

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12
Q

Sulfonylureas SEs

A

1st gen&raquo_space; Disulfuram

2nd gen&raquo_space; Hypoglycemia

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13
Q

Pioglitazone, Rosiglitazone MOA

A

Glitazones / Thiazolidinediones

increase insulin sensitivity via PPAR gamma nuclear transcription regulator

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14
Q

Acarbose, Miglitol MOA

A

Alpha glucosidase inhibitors

inhibit intestinal border alpha glucosidases&raquo_space; decreased glucose absorption

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15
Q

Miglitol SEs

A

GI disturbances

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16
Q

Pramlintide MOA

A

Amylin analog

Decrease gastric emptying, glucagon

17
Q

Pramlintide SEs

A

Hypoglycemia, nausea, diarrhea

18
Q

Exenatide, Liraglutide MOA

A

GLP-1 analogs

increased insulin
decreased glucagon

19
Q

Linagliptin, Saxagliptin, Sitagliptin

A

DPP-4 inhibitors

20
Q

Linagliptin, Saxagliptin, Sitagliptin MOA

A

Increase insulin

Decrease glucagon release

21
Q

Linagliptin, Saxagliptin, Sitagliptin SEs

A

Mild urinary / resp infections

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